Preliminary Effects of Oral Uridine on the Ocular Surface in Dry Eye Patients.
10.3346/jkms.2009.24.4.701
- Author:
Ki Cheol CHANG
1
;
Joo Youn OH
;
Youn Seok IN
;
Mee Kum KIM
;
Ki Cheul SHIN
;
Won Ryang WEE
;
Jin Hak LEE
;
Myung Gyu PARK
Author Information
1. Department of Ophthalmology, Seoul National University College of Medicine and Seoul National University Hospital Clinical Research Institute, Seoul, Korea. kmk9@snu.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
- Keywords:
Cornea;
Dry Eye Syndromes;
Uridine;
OSDI
- MeSH:
Administration, Oral;
Adolescent;
Adult;
Aged;
Conjunctiva/pathology;
Cornea/pathology;
Double-Blind Method;
Dry Eye Syndromes/*drug therapy;
Female;
Fluorescent Dyes/pharmacology;
Humans;
Male;
Middle Aged;
Severity of Illness Index;
Uridine/administration & dosage/*therapeutic use
- From:Journal of Korean Medical Science
2009;24(4):701-707
- CountryRepublic of Korea
- Language:English
-
Abstract:
We designed a randomized, double blinded, 3-months controlled prospective clinical study to investigate effects of oral uridine on the ocular surface in dry eye patients. Twenty-seven patients who diagnosed as dry eye with lower than 5 mm of wetting in the Schirmer strip, with corneal epithelial erosion and who completely followed-up till 3 months were enrolled. Corneal-conjunctival fluorescein staining, non-anesthetic Schirmer test, impression cytology, and Ocular Surface Disease Index (OSDI) were evaluated in the experimental and placebo groups at the baseline, 1 and 3 months after start of medication in a double blinded manner. Fluorescein stain score of the cornea was markedly decreased in oral uridine group compared to the placebo group at 3 months after medication (P=0.032, Mann-Whitney U test). The Schirmer wetting score for the oral uridine group was significantly increased (P=0.001, Wilcoxon signed rank test) at 3 months and its difference between two groups was statistically significant (P=0.030, Mann-Whitney U test). OSDI scores were significantly decreased at 1 and 3 months in treatment group. Oral uridine is effective in treatment of dry eyes.
