A Case of Prothionamide Induced Hepatitis on Patient with Multi-Drug Resistant Pulmonary Tuberculosis.
10.4046/trd.2011.70.3.251
- Author:
Jun Beom PARK
1
;
Byung Hoon PARK
;
Ji Young SON
;
Ji Ye JUNG
;
Eun Young KIM
;
Ju Eun LIM
;
Sang Hoon LEE
;
Sang Kook LEE
;
Song Yee KIM
;
Wonjai JUNG
;
Seungtaek LIM
;
Kyung Jong LEE
;
Young Ae KANG
;
Young Sam KIM
;
Se Kyu KIM
;
Joon CHANG
;
Junjeong CHOI
;
Moo Suk PARK
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. pms70@yuhs.ac
- Publication Type:Case Report
- Keywords:
Tuberculosis, Multidrug-Resistant;
Hepatitis;
Prothionamide
- MeSH:
Biopsy;
Drug-Induced Liver Injury;
Fever;
Hepatitis;
Humans;
Isoniazid;
Korea;
Liver;
Male;
Prevalence;
Prothionamide;
Reference Values;
Rifampin;
Tuberculosis, Multidrug-Resistant;
Tuberculosis, Pulmonary
- From:Tuberculosis and Respiratory Diseases
2011;70(3):251-256
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The prevalence of multi-drug resistant tuberculosis (MDR-TB), which is resistant to isoniazid and rifampin, has been increasing in Korea. And the side effects of 2nd line anti-tuberculosis medications, including drug-induced hepatitis, are well known. Although prothionamide (PTH) is one of the most useful anti-TB medications and although TB medication-induced acute hepatitis is a severe complication, there are only a few published case reports about prothionamide induced hepatitis. In this case report, a 22 year old male was diagnosed with pulmonary MDR-TB and was administered 2nd line anti-TB mediations, including PTH. Afterwards, he had a spiking fever and his liver enzymes were more than 5 times greater than the upper limit of the normal range. He was then diagnosed with drug-induced hepatitis by liver biopsy. His symptoms and liver enzyme elevation were improved after stopping PTH. Accordingly, we report this case of an association between PTH and acute hepatitis.
