Comparative Analysis of Squamous Cell Differentiation by Histologic Subtypes in Basal Cell Carcinoma.
- Author:
Shin Taek OH
1
;
Su Jean CHONG
;
Chul Jong PARK
;
Young Min PARK
;
Sang Hyun CHO
;
Jun Young LEE
;
Jin Woo KIM
;
Si Yong KIM
;
Baik Kee CHO
Author Information
1. Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Basal cell carcinoma;
Basosquamous carcinoma;
Squamous differentiation
- MeSH:
Carcinoma, Basal Cell*;
Carcinoma, Basosquamous;
Cell Differentiation*;
Hospitals, Satellite;
Korea
- From:Korean Journal of Dermatology
2005;43(11):1475-1481
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: There has been no general agreement on classifying basal cell carcinoma (BCC), and little is known about the squamous cell differentiations of each subtype of BCC. BCC is a locally-invasive tumor, but its aggressive forms tend to recur and metastasize. OBJECTIVE: We have compared the histolopathological subtypes of BCC by squamous differentiation, with special emphasis on basosquamous carcinoma and the difference between the non- aggressive and aggressive forms of BCC. MATERIALS AND METHOD: A total of 87 BCC specimens were collected from the 7 branch hospitals of The Catholic University of Korea from July 1997 to June 2003. RESULTS: 1. The 87 samples were divided into 6 subtypes: 18 nodular, 19 nodular infiltrative, 12 micronodular, 14 infiltrative, 11 morpheaform, 13 basosquamous. Overall, 18 samples were classified as non- aggressive and the remaining 69 as aggressive. 2.In nodular-infiltrative BCC and basosquamous carcinoma, squamous cell differentiation was significantly more prominent than in the nodular BCC. CONCLUSION: Squamous cell differentiation should be considered as one of the aggressive markers, especially in nodule-forming BCC.
