A Case of Oseltamivir-Resistant Pandemic Influenza (H1N1 2009) in a Patient with Acute Myeloid Leukemia.
- Author:
Yo Han LEE
1
;
Hyo Youl KIM
;
Hyun Soo KIM
;
Young UH
;
Young Keun KIM
;
Bo Ra KIM
;
Ho Yeon JUNG
;
Woo Taek KIM
;
Hwajung YI
Author Information
- Publication Type:Case Report
- Keywords: Pandemic influenza (H1N1 2009); Oseltamivir; Antiviral resistance; Leukemia
- MeSH: Humans; Influenza, Human; Inhalation; Leukemia; Leukemia, Myeloid, Acute; Middle Aged; Oseltamivir; Pandemics; Republic of Korea; Viruses; Zanamivir
- From:Infection and Chemotherapy 2010;42(2):107-111
- CountryRepublic of Korea
- Language:Korean
- Abstract: Oseltamivir is the drug of choice for patients with pandemic influenza (H1N1 2009). However, sporadic cases of oseltamivir resistance have been described worldwide. Up to March 2010, a total of 11 strains (2.2% of tested isolates) of oseltamivir-resistant pandemic influenza (H1N1 2009) have been discovered in South Korea. We report a case of 46-year-old man with acute myeloid leukemia in whom an oseltamivir-resistant pandemic (H1N1) 2009 virus was isolated. Despite high dose oseltamivir therapy for 10 days he had persistent symptoms and showed positive results in repeated real-time RT-PCR for pandemic influenza (H1N1 2009) virus from nasopharyngeal specimen. The patient improved eventually after oseltamivir was replaced by zanamivir inhalation.
