Executive Dysfunction in Obsessive-Compulsive Disorder and Anterior Cingulate-Based Resting State Functional Connectivity.
- Author:
Je Yeon YUN
1
;
Joon Hwan JANG
;
Wi Hoon JUNG
;
Na Young SHIN
;
Sung Nyun KIM
;
Jae Yeon HWANG
;
Jun Soo KWON
Author Information
- Publication Type:Original Article
- Keywords: Obsessive-compulsive disorder; Executive function; Anterior cingulate cortex; Resting state functional connectivity network
- MeSH: Automatic Data Processing; Drug Therapy; Executive Function; Foundations; Frontal Lobe; Gyrus Cinguli; Obsessive-Compulsive Disorder*; Prefrontal Cortex; Reaction Time; Task Performance and Analysis; Trail Making Test; Wisconsin
- From:Psychiatry Investigation 2017;14(3):333-343
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: Executive dysfunction might be an important determinant for response to pharmacotherapy in obsessive-compulsive disorder (OCD), and could be sustained independently of symptom relief. The anterior cingulate cortex (ACC) has been indicated as a potential neural correlate of executive functioning in OCD. The present study examined the brain-executive function relationships in OCD from the ACC-based resting state functional connectivity networks (rs-FCNs), which reflect information processing mechanisms during task performance. METHODS: For a total of 58 subjects [OCD, n=24; healthy controls (HCs), n=34], four subdomains of executive functioning were measured using the Rey-Osterrieth Complex Figure Test (RCFT), the Stroop Color-Word Test (SCWT), the Wisconsin Card Sorting Test (WCST), and the Trail Making Test part B (TMT-B). To probe for differential patterns of the brain-cognition relationship in OCD compared to HC, the ACC-centered rs-FCN were calculated using five seed regions systemically placed throughout the ACC. RESULTS: Significant differences between the OCD group and the HCs with respect to the WCST perseverative errors, SCWT interference scores, and TMT-B reaction times (p<0.05) were observed. Moreover, significant interactions between diagnosis×dorsal ACC [S3]-based rs-FCN strength in the right dorsolateral prefrontal cortex for RCFT organization summary scores as well as between diagnosis×perigenual ACC [S7]-based rs-FCN strength in the left frontal eye field for SCWT color-word interference scores were unveiled. CONCLUSION: These network-based neural foundations for executive dysfunction in OCD could become a potential target of future treatment, which could improve global domains of functioning broader than symptomatic relief.
