Nucleotide sequence analysis of HTLV-I isolate from a Korean patient with HAM/TSP.
10.3349/ymj.1993.34.4.321
- Author:
Mineki SAITO
1
;
Takashi MORITOYO
;
Jae Hyeon PARK
;
Byung In LEE
;
Jin Soo KIM
;
Jun ichi FUJISAWA
;
Mitsuhiro OSAME
;
Mitsuaki YOSHIDA
Author Information
1. Department of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, Shirokanedai, Minatoku, Tokyo, Japan.
- Publication Type:Case Reports
- Keywords:
HTLV-I;
HAM/TSP;
polymerase chain reaction;
nucleotide sequence analysis
- MeSH:
Adult;
Base Sequence;
Case Report;
DNA, Viral/genetics;
Human;
Human T-lymphotropic virus 1/*genetics/isolation & purification;
Korea/ethnology;
Male;
Molecular Probes/genetics;
Molecular Sequence Data;
Paraparesis, Tropical;
Spastic/epidemiology/ethnology/*genetics/*microbiology
- From:Yonsei Medical Journal
1993;34(4):321-327
- CountryRepublic of Korea
- Language:English
-
Abstract:
Limited nucleotide sequences of human T-cell lymphotropic virus type I (HTLV-1) provirus isolated from the first case of a Korean patient with HTLV-I associated myelopathy and tropical spastic paraparesis (HAM/TSP) were analysed and compared with other isolates from different regions of the world. The sequences of the env, LTR regions (536bp, 690bp respectively) showed 98.7%, 99.3% homologies with the prototype HTLV-I, ATK-1, isolated from a Japanese Adult T-cell leukemia (ATL) patient. A comparison between other isolates from different geographical origins revealed that the Korean HTLV-I isolate is more closely related to Japanese isolates than to those from other geographical origins
