Very-Late Onset Diffuse Large B-cell Lymphoma with CD3 Coexpression in a Kidney Transplant Patient.
- Author:
Biro KIM
1
;
Sungjin CHUNG
;
Seok hui KANG
;
Seok Goo CHO
;
Cheol Whee PARK
;
Yoon Sik CHANG
Author Information
1. Division of Nephrology, Department of Internal Medicine, Sanggye-Paik Hospital, The Inje University, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Neoplasm transplantation;
Lymphoproliferative disorder;
Diffuse large B-cell lymphoma
- MeSH:
B-Lymphocytes;
Dyspepsia;
Endoscopy, Digestive System;
Follow-Up Studies;
Humans;
Kidney;
Kidney Failure, Chronic;
Lymphoma, B-Cell;
Lymphoma, Non-Hodgkin;
Lymphoproliferative Disorders;
Male;
Middle Aged;
Neoplasm Transplantation;
Pyloric Antrum;
Recurrence;
T-Lymphocytes;
Transplants;
Ulcer
- From:Korean Journal of Nephrology
2011;30(6):689-693
- CountryRepublic of Korea
- Language:English
-
Abstract:
B-lineage non-Hodgkin lymphoma may aberrantly coexpress T-cell markers. In general population, however, cases of diffuse large B-cell lymphomas with CD3 co-expression are rare because the CD3 marker is the most lineage specific T-cell antigen. We report a case of CD3 coexpressed diffuse large B-cell lymphoma in a 47-year-old male patient presented with dyspepsia who had transplanted a kidney 17 years ago. An esophagogastroduodenoscopy displayed an ulcerated mass in the gastric antrum. The pathology of the mass was monomorphic post-transplant lymphoproliferative disorder - specifically, CD20- and CD3-positive diffuse large B-cell lymphoma. Resection of the mass and postop chemotherapy were performed. A follow-up computerized tomography showed disapperance of tumor. No recurrence was observed until 7 month after treatment. Nevertheless, the patient's renal function gradually aggrevated and progressed to end stage renal disease. As far as we know, this is the first case of diffuse large B-cell lymphoma with CD3 coexpression after kidney transplant.
