Interaction between Genetic Polymorphisms of CYP2E1 & NAT1 and Smoking in Lung Cancer Development (Preliminary report).
- Author:
Kyoung Mu LEE
1
;
Seung Joon LEE
;
Sue Kyung PARK
;
Sang Yun LEE
;
Hyung June IM
;
Ki Jung YOON
;
In Mi CHOI
;
Young Ju LEE
;
Soo Ung KIM
;
Hwang CHOI
;
Seung Ho CHOI
;
Young Whan KIM
;
Soo Han CHO
;
Daehee KANG
Author Information
1. Department of Preventive Medicine, Seoul National University College of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Lung neoplasm;
Smoking;
Cytochrome P450 2E1;
N-acetyltransferase 1;
Interaction
- MeSH:
Alleles;
Case-Control Studies;
Cytochrome P-450 CYP2E1*;
Cytochromes;
Digestion;
Gene-Environment Interaction;
Genotype;
Humans;
Lung Neoplasms*;
Lung*;
Male;
Polymorphism, Genetic*;
Smoke*;
Smoking*;
Urology
- From:Journal of the Korean Cancer Association
2001;33(1):41-48
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The interactive effects of genetic polymorphisms of cytochrome P4502E1 (CYP2E1) & N-acetyltransferase 1 (NAT1) and smoking on lung cancer development were evaluated in hospital based case-control study. MATERIALS AND METHODS: Male lung cancer patients (N= 157) and the male patients with no present or previous history of systemic illnesses who visited the urology department (N=138) were recruited (1998-1999). CYP2E1 & NAT1 genotypes were determined by PCR-RFLP method using RsaI and MboII digestion, respectively. RESULTS: CYP2E1 c2 or NAT1 *10 allele did not increased the risk of lung cancer. Heavy smokers (35
