Relationship between 15-hydroxyprostaglandin dehydrogenase and gastric adenocarcinoma.
10.4174/astr.2014.86.6.302
- Author:
Jae Hyun KANG
1
;
Sang Hyun KANG
;
Sang Hyuk SEO
;
Jae Ho SHIN
;
Min Sung AN
;
Tae Kwun HA
;
Ki Beom BAE
;
Tae Hyun KIM
;
Chang Soo CHOI
;
Sang Hoon OH
;
Mi Seon KANG
;
Kwang Hee KIM
Author Information
1. Department of Surgery, Inje University College of Medicine, Busan, Korea. inwoodog@naver.com
- Publication Type:Original Article
- Keywords:
Gastric neoplasms;
15-Hydroxyprostaglandin dehydrogenase;
Differentiation;
Staging
- MeSH:
Adenocarcinoma*;
Dinoprostone;
Humans;
Lymph Nodes;
Neoplasm Metastasis;
Oxidoreductases*;
Retrospective Studies;
Stomach Neoplasms
- From:Annals of Surgical Treatment and Research
2014;86(6):302-308
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Prostaglandin E2 (PGE2) is a contributory carcinogen in gastric adenocarcinoma. 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) catabolizes PGE2 by oxidizing its 15(s)-hydroxy group. The aim of this study was to investigate the expression of 15-PGDH in gastric adenocarcinoma tissue and the relationship between 15-PGDH expression and clinicopathologic features of gastric adenocarcinoma. METHODS: Ninety-nine patients who underwent surgical resection for gastric adenocarcinoma between January 2007 and December 2007 were enrolled and evaluated retrospectively. RESULTS: In 62 patients (62.6%), 15-PGDH expression was lower in gastric adenocarcinoma tissue than in nonneoplastic tissue. Regarding the relationship between 15-PGDH expression and clinicopathological features, 15-PGDH expression was significantly lower in tissues with poor differentiation (P = 0.002), advanced T stage (P = 0.0319), a higher number of lymph node metastases (P = 0.045), lymphatic invasion (P = 0.031), and vascular invasion (P = 0.036). CONCLUSION: 15-PGDH expression was associated with a subset of clinicopathologic features such as differentiation grade, T stage, lymphatic invasion, and vascular invasion.
