Lipase Supplementation before a High-Fat Meal Reduces Perceptions of Fullness in Healthy Subjects.
- Author:
Max E LEVINE
1
;
Sara Yanchis KOCH
;
Kenneth L KOCH
Author Information
- Publication Type:Original Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
- Keywords: Lipase supplementation; Gastric myoelectrical activity; Electrogastrography; Dyspepsia symptoms; Fullness; Acid-resistant lipase
- MeSH: Abdominal Pain/etiology/psychology; Adult; Cross-Over Studies; Diet, High-Fat/*adverse effects/psychology; *Dietary Supplements; Double-Blind Method; Dyspepsia/etiology/*prevention & control/psychology; Female; Gastrointestinal Motility/drug effects/physiology; Healthy Volunteers; Humans; Lipase/*administration & dosage; Male; Meals; Middle Aged; Myoelectric Complex, Migrating; Nausea/etiology/psychology; Postprandial Period; Stomach/*drug effects/physiology; Young Adult
- From:Gut and Liver 2015;9(4):464-469
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Postprandial symptoms of fullness and abdominal discomfort are common after fatty meals. Gastric lipases hydrolyze 10% to 20% of dietary triglycerides during the stomach trituration period of digestion. The aim of this study was to evaluate the effects of acid-resistant lipase on upper gastrointestinal symptoms, including fullness and bloating, as well as on gastric myoelectrical activity after healthy subjects ingested a high-fat, liquid meal. METHODS: This study utilized a double-blind, placebo-controlled, crossover design with 16 healthy volunteers who ingested either a capsule containing 280 mg of acid-resistant lipase or a placebo immediately before a fatty meal (355 calories, 55% fat). Participants rated their stomach fullness, bloating, and nausea before and at timed intervals for 60 minutes after the meal. Electrogastrograms were obtained to assess the gastric myoelectrical activity. RESULTS: Stomach fullness, bloating, and nausea increased significantly 10 minutes after ingestion of the fatty meal (p<0.01), whereas normal gastric myoelectrical activity decreased and tachygastria increased (p<0.05). With lipase, reports of stomach fullness were significantly lower compared with placebo (p<0.05), but no effect on gastric myoelectrical activity or other upper gastrointestinal symptoms was observed. CONCLUSIONS: The high-fat meal induced transient fullness, bloating, nausea, and tachygastria in healthy individuals, consistent with post-prandial distress syndrome. Acid-resistant lipase supplementation significantly decreased stomach fullness.
