Antidiabetic Effects of Corni Fructus Extract in Streptozotocin-Induced Diabetic Rats.
10.3349/ymj.2012.53.4.691
- Author:
Dawei GAO
1
;
Qingwang LI
;
Zhengrong GAO
;
Lixin WANG
Author Information
1. Department of Biological Engineering, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, China. dwgao@ysu.edu.cn
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Corni Fructus (Cornus officinalis Sieb. et Zucc.);
diabetic nephropathy;
peroxisome proliferator-activated receptor-gamma (PPARgamma);
antioxidant enzymes
- MeSH:
Animals;
Blotting, Western;
Body Weight/drug effects;
Catalase/metabolism;
Cornus/*chemistry;
Diabetes Mellitus, Experimental/*drug therapy;
Glucose Tolerance Test;
Glutathione/metabolism;
Hypoglycemic Agents/*therapeutic use;
Male;
Malondialdehyde/metabolism;
Plant Extracts/*therapeutic use;
Rats;
Rats, Wistar;
Reverse Transcriptase Polymerase Chain Reaction;
Superoxide Dismutase/metabolism
- From:Yonsei Medical Journal
2012;53(4):691-700
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Diabetes is the leading cause of end-stage renal failure. The present study was undertaken to characterize the effects of Corni Fructus on diabetic nephropathy in streptozotocin-induced diabetic rats and their mechanisms. MATERIALS AND METHODS: Streptozotocin-diabetic rats were orally administrated with Corni Fructus at a dose of 100, 200 or 400 mg/kg body mass for 40 days. RESULTS: Corni Fructus-treated diabetic rats showed significant decreases of blood glucose, urinary protein levels and water consumption. Corni Fructus also reduced serum total cholesterol, total triglyceride and low-density lipoprotein cholesterol levels, and showed a tendency of enhancing high-density lipoprotein cholesterol level. Levels of serum albumin and creatinine in diabetic rats were also significantly reduced by Corni Fructus administration at a dose of 200 and 400 mg/kg body mass compared with non-treated diabetic rats. Corni Fructus increased catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidose (GSH-px) activities in the kidneys of diabetic rats. Furthermore, Corni Fructus treatment enhanced renal peroxisome proliferator-activated receptor-gamma (PPARgamma) expression in diabetic rats. CONCLUSION: These results demonstrated that Corni Fructus may have the potential to protect the animals from diabetic nephropathy by amelioration of oxidative stress and stimulation of PPARgamma expression.
