Annual Change in Pulmonary Function and Clinical Characteristics of Combined Pulmonary Fibrosis and Emphysema and Idiopathic Pulmonary Fibrosis: Over a 3-Year Follow-up.
- Author:
Yu Jin KIM
1
;
Seong Hyun SHIN
;
Jeong Woong PARK
;
Sun Young KYUNG
;
Shin Myung KANG
;
Sang Pyo LEE
;
Yon Mi SUNG
;
Yoon Kyung KIM
;
Sung Hwan JEONG
Author Information
- Publication Type:Original Article
- Keywords: Pulmonary Emphysema; Pulmonary Fibrosis; Idiopathic Pulmonary Fibrosis; Respiratory Function Tests
- MeSH: Blood Sedimentation; Carbon Monoxide; Comorbidity; Cough; Diffusion; Emphysema*; Follow-Up Studies*; Forced Expiratory Volume; Hospitalization; Humans; Idiopathic Pulmonary Fibrosis*; Intention; Pneumonia; Pulmonary Emphysema; Pulmonary Fibrosis*; Respiratory Function Tests; Retrospective Studies; Sputum; Vital Capacity
- From:Tuberculosis and Respiratory Diseases 2014;77(1):18-23
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Combined pulmonary fibrosis and emphysema (CPFE) have different pulmonary function tests (PFTs) and outcomes than idiopathic pulmonary fibrosis (IPF). The intention of this study was to identify unknown differences between CPFE and IPF by a retrospective comparison of clinical data including baseline and annual changes in pulmonary function, comorbidities, laboratory findings, clinical characteristics and cause of hospitalization. METHODS: This study retrospectively enrolled patients with CPFE and IPF who had undergone PFTs once or several times per year during a follow-up period of three years. Baseline clinical characteristics and the annual changes in the pulmonary function during the follow-up period were compared between 26 with CPFE and 42 patients with IPF. RESULTS: The baseline ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC%) in patients with CPFE was lower than that in patients with IPF (78.6+/-1.7 vs. 82.9+/-1.1, p=0.041). The annual decrease in FEV1/FVC in the CPFE was significantly higher than in the IPF. The annual decreases in diffusion capacity of carbon monoxide and FVC showed no significant differences between the two groups. The symptom durations of cough and sputum were in the CPFE significantly lower than in the IPF. The serum erythrocyte sedimentation rate level at the acute stage was significantly higher than in the IPF. There were no significant differences in the hospitalization rate and pneumonia was the most common cause of hospitalization in both study groups. CONCLUSION: The annual decrease of FEV1/FVC was in patients with CPFE significantly higher than in the patients with IPF.
