Weight Gain and Improvement of Osteoporosis with Anti-TNF Therapy.
- Author:
Tae Hwan KIM
1
;
Hyaejin YUN
Author Information
1. Hanyang University Hospital for Rheumatic Diseases, Hanyang University College of Medicine, Seoul, Korea. thkim@hanyang.ac.kr
- Publication Type:Editorial
- Keywords:
Anti-TNF;
Osteoporosis;
Weight gain
- MeSH:
Anti-Inflammatory Agents, Non-Steroidal;
Back Pain;
Humans;
Osteogenesis;
Osteoporosis*;
Sacroiliac Joint;
Spine;
Spondylitis, Ankylosing;
Weight Gain*
- From:Korean Journal of Medicine
2013;85(5):485-488
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Ankylosing spondylitis (AS) is a chronic inflammatory disorder primarily involving the sacroiliac joints and spine. It usually affects young people, and bone formation and resorption are implicated in the pathogenesis of AS. Non-steroidal anti-inflammatory drugs (NSAIDs) are the first line therapy and are very effective in most of patients who have inflammatory back pain. If NSAIDs are not effective, anti-TNF-alpha agents are strongly recommended in severe inflammatory back pain. Anti-TNF-alpha is very effective in most of AS patients. A study by Lee et al. showed that AS patients who were treated with anti-TNF-alpha have weight gain and improvement of osteoporosis. In this editorial, studies on the improvement of weight and osteoporosis with anti-TNF-alpha agents are reviewed.
