Association of Exercise-Induced Asthma with Atopy in Adult Patients with Asthma-Like Symptoms.
- Author:
Jin Hyung HAN
1
;
Byung Woon KWON
;
Kyung Hee HYUN
;
Young Hyun KIM
;
Hyun Suk LEE
;
Do Hyung KIM
;
Yon Seop KIM
;
Jae Suk PARK
;
Kyung Mook KIM
;
Young Koo JEE
Author Information
1. Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea. ykjee@dku.edu
- Publication Type:Original Article
- Keywords:
Exercise-induced asthma;
Atopy;
Bronchial hyperreactivity
- MeSH:
Adult;
Allergens;
Asthma;
Asthma, Exercise-Induced;
Bronchial Hyperreactivity;
Dermatophagoides farinae;
Dermatophagoides pteronyssinus;
Humans;
Male;
Methacholine Chloride;
Pollen;
Pyroglyphidae;
Risk Factors;
Skin;
Young Adult
- From:Korean Journal of Medicine
2011;81(6):723-728
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Atopy is closely related to asthma and is a risk factor for the development and exacerbation of asthma. The aim of this study was to evaluate the association between exercise-induced asthma (EIA) and atopy in adult patients with asthma-like symptoms. METHODS: Forty young male patients with asthma-like symptoms were enrolled. Skin prick, methacholine bronchial provocation, and exercise provocation tests were performed. Current and ex-smokers were excluded. RESULTS: Exercise provocation tests were positive in 21 patients (52.5%). Airway hyperresponsiveness (AHR) to methacholine (85.7% vs. 42.1%, p = 0.007) and atopy (85.7% vs. 47.4, p = 0.017) was found more frequently in patients with EIA than in those without EIA. EIA was significantly associated with atopy score (16.5 +/- 3.0 vs. 6.5 +/- 2.0, p = 0.011), atopy index (2.1 +/- 0.3 vs. 1.0 +/- 0.3, p = 0.004), and positive responses to Dermatophagoides pteronyssinus (76.2% vs. 42.1%, p = 0.028) and Dermatophagoides farinae (76.2% vs. 36.8%, p = 0.012), but not with positive responses to pollen allergens. AHR to methacholine (odds ratio [OR]: 14.3, 95% confidence interval [CI]: 1.86-109.4) and atopy (OR: 16.9, 95% CI: 2.04-140.74) were significant risk factors for EIA. CONCLUSIONS: Atopy was a risk factor for EIA in young adult men, and sensitization to house dust mites was associated with EIA.
