Anaplastic Large Cell Lymphoma Involving Anterior Segment of the Eye.
10.3341/kjo.2014.28.1.108
- Author:
Choul Yong PARK
1
;
Sang Won HWANG
;
Do Yeun KIM
;
Hee Jin HUH
;
Jong Hyun OH
Author Information
1. Department of Ophthalmology, Dongguk University Seoul, Graduate School of Medicine, Seoul, Korea. blueretinaoh@gmail.com
- Publication Type:Case Reports ; Research Support, Non-U.S. Gov't
- Keywords:
Acute angle closure;
Anaplastic large cell lymphoma;
Eye;
Radiotherapy
- MeSH:
Adult;
Anterior Eye Segment/*pathology;
Biopsy;
Diagnosis, Differential;
Eye Neoplasms/*diagnosis;
Female;
Humans;
Lymphoma, Large-Cell, Anaplastic/*diagnosis;
Magnetic Resonance Imaging;
*Neoplasm Invasiveness;
Positron-Emission Tomography
- From:Korean Journal of Ophthalmology
2014;28(1):108-112
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 36-year-old woman was diagnosed with anaplastic large cell lymphoma (ALCL) by excisional biopsy of a left frontal skin lesion. During the first cycle of chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisolone), the patient complained of right ocular pain and inflammation. Cytologic examination using aqueous humor revealed atypical lymphocytes, suggesting intraocular ALCL involvement. Acute angle closure developed in the anterior chamber due to rapid progression of ALCL, causing pupillary block. Laser and surgical interventions were attempted but failed to relieve the pupillary block. Finally, radiation therapy resolved the pupillary block to restore the anterior chamber and normalize intraocular pressure. This is the first case in the English literature of ALCL involving the iris to cause acute secondary angle closure.
