Hemophagocytic Syndrome in a Patient with Acute Tubulointerstitial Nephritis Secondary to Hepatitis A Virus Infection.
10.3346/jkms.2010.25.10.1529
- Author:
Eunjung CHO
1
;
Inhye CHA
;
Kichul YOON
;
Ha Na YANG
;
Hye Won KIM
;
Myung Gyu KIM
;
Sang Kyung JO
;
Won Yong CHO
;
Hyoung Kyu KIM
Author Information
1. Department of Internal Medicine, Korea University Medical College, Korea University Anam Hospital, Seoul, Korea. sang-kyung@korea.ac.kr
- Publication Type:Case Report
- Keywords:
Acute Hepatitis A;
Acute Kidney Injury;
Lymphohistiocytosis, Hemophagocytic
- MeSH:
Acute Disease;
Acute Kidney Injury/diagnosis/therapy;
Antibodies, Viral/analysis;
Hepatitis A/complications/*diagnosis/immunology;
Humans;
Lymphohistiocytosis, Hemophagocytic/complications/*diagnosis/pathology;
Macrophages/immunology;
Male;
Middle Aged;
Nephritis, Interstitial/complications/*diagnosis;
Renal Dialysis;
T-Lymphocytes/immunology
- From:Journal of Korean Medical Science
2010;25(10):1529-1531
- CountryRepublic of Korea
- Language:English
-
Abstract:
Hepatitis A virus (HAV) infection is generally a self-limited disease, but the infection in adults can be serious, to be often complicated by acute kidney injury (AKI) and rarely by virus-associated hemophagocytic syndrome (VAHS). Our patient, a 48-yr-old man, was diagnosed with HAV infection complicated by dialysis-dependent AKI. His kidney biopsy showed acute tubulointerstitial nephritis with massive infiltration of activated macrophages and T cells, and he progressively demonstrated features of VAHS. With hemodialysis and steroid treatment, he was successfully recovered.
