Immunohistochemical Study of the Expression of Astrocyte Elevated Gene-1 (AEG-1) in Malignant Melanoma, Spitz Nevus and Dysplastic Nevus.
- Author:
Byung Chul KIM
1
;
Na Reu SEUNG
;
Eun Joo PARK
;
In Ho KWON
;
Kwang Ho KIM
;
Kwang Joong KIM
;
Hye Rim PARK
Author Information
1. Department of Dermatology, College of Medicine, Hallym University, Chuncheon, Korea. dermakkh@yahoo.co.kr
- Publication Type:Original Article
- Keywords:
Astrocyte elevated gene-1;
Dysplastic nevus;
Malignant melanoma;
Spitz nevus
- MeSH:
Astrocytes;
Biopsy;
Breast Neoplasms;
Clone Cells;
Dysplastic Nevus Syndrome;
Glioblastoma;
HIV-1;
Humans;
Melanocytes;
Melanoma;
Necrosis;
Nevus;
Nevus, Epithelioid and Spindle Cell
- From:Korean Journal of Dermatology
2011;49(4):334-338
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The astrocyte elevated gene-1 (AEG-1) was cloned as a novel HIV-1 and tumor necrosis factor-alpha-induced transcript from primary human fetal astrocytes. It has been reported that the AEG-1 expression is elevated in subsets of breast cancer, glioblastoma multiforme and melanoma cells, and AEG-1 cooperates with Ha-ras to promote the transformation of immortalized melanocytes. AEG-1 is thought to play a role in promoting cancer development and/or its maintenance. OBJECTIVE: The aim of this study is to determine whether AEG-1 is related to the pathogenesis of melanoma and other melanocytic lesions. METHODS: The nine biopsy specimens each of melanoma, dysplastic nevus, Spitz nevus and compound nevus were studied using immunohistochemical staining. The expressions of AEG-1 were evaluated using an immunostaining-intensity-distribution index. RESULTS: The expression of AEG-1 was significantly higher in the melanoma and dysplastic nevus than in the compound nevus. The expression was also significantly higher in the melanoma than in the Spitz nevus. CONCLUSION: AEG-1 may be related to the pathogenesis of both dysplastic nevus and melanoma, but it may not be related to Spitz nevus.
