Rhabdomyolysis and Acute Kidney Injury Associated with Hypothyroidism and Statin Therapy.
10.3803/EnM.2013.28.4.331
- Author:
Pyoung AHN
1
;
Hyun Jun MIN
;
Sang Hyun PARK
;
Byoung Mu LEE
;
Myung Jin CHOI
;
Jong Woo YOON
;
Ja Ryong KOO
Author Information
1. Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea.
- Publication Type:Case Report
- Keywords:
Hypothyroidism;
Rhabdomyolysis;
Statins
- MeSH:
Acute Kidney Injury*;
Female;
Hemofiltration;
Humans;
Hydroxymethylglutaryl-CoA Reductase Inhibitors*;
Hypercholesterolemia;
Hypothyroidism*;
Middle Aged;
Muscle, Skeletal;
Muscles;
Myoglobin;
Rhabdomyolysis*
- From:Endocrinology and Metabolism
2013;28(4):331-334
- CountryRepublic of Korea
- Language:English
-
Abstract:
Rhabdomyolysis is a syndrome involving the breakdown of skeletal muscle that causes myoglobin and other intracellular proteins to leak into the circulatory system, resulting in organ injury including acute kidney injury. We report a case of statin-induced rhabdomyolysis and acute kidney injury that developed in a 63-year-old woman with previously undiagnosed hypothyroidism. Untreated hypothyroidism may have caused her hypercholesterolemia requiring statin treatment, and it is postulated that statin-induced muscle injury was aggravated by hypothyroidism resulting in her full-blown rhabdomyolysis. Although this patient was successfully treated with continuous venovenous hemofiltration and L-thyroxin replacement, rhabdomyolysis with acute kidney injury is a potentially life-threatening disorder. Physicians must pay special attention to the possible presence of subclinical hypothyroidism when administering statins in patients with hypercholesterolemia.
