Serum Levels of IL-8 and ICAM-1 as Biomarkers for Progressive Massive Fibrosis in Coal Workers' Pneumoconiosis.
10.3346/jkms.2015.30.2.140
- Author:
Jong Seong LEE
1
;
Jae Hoon SHIN
;
Byung Soon CHOI
Author Information
1. Occupational Lung Diseases Institute, Korea Workers' Compensation & Welfare Service, Incheon, Korea. ljs5075@hanmail.net
- Publication Type:Original Article
- Keywords:
Coal Workers' Pneumoconiosis;
Intercellular Adhesion Molecule-1;
Interleukin-8;
Macrophage Inflammatory Protein-1 Alpha;
Progressive Massive Fibrosis
- MeSH:
Aged;
Anthracosis/*blood/pathology;
Biological Markers/blood;
Chemokine CCL3/*blood;
Coal Mining;
Humans;
Intercellular Adhesion Molecule-1/*blood;
Interleukin-8/*blood;
Lung/pathology;
Male;
Middle Aged;
Occupational Diseases/blood/pathology;
Pulmonary Fibrosis/*blood/pathology
- From:Journal of Korean Medical Science
2015;30(2):140-144
- CountryRepublic of Korea
- Language:English
-
Abstract:
Coal workers' pneumoconiosis (CWP) is characterized as a chronic inflammation of the lung associated with activation of macrophages and endothelial cells in the lung. The aim of the present study was to compare the levels of serum interleukin-8 (IL-8), macrophage inflammatory protein-1alpha (MIP-alpha), and intercellular adhesion molecule-1 (ICAM-1) as biomarkers for progressive massive fibrosis (PMF) in 106 subjects (27 non-CWP and 79 CWP patients). The levels of serum IL-8 (P<0.001) and ICAM-1 (P=0.001) of subjects with PMF were higher than those of non-CWP subjects. The IL-8 levels of PMF subjects were also higher than those of simple CWP subjects (P=0.003). Among the subjects without PMF, IL-8 levels in the subjects with International Labour Organization (ILO) category II or III were higher than those in the subjects with ILO category 0 (P=0.006) and with category I (P=0.026). These results suggest that high serum levels of IL-8 and ICAM-1, which are important as neutrophil attractants and adhesion molecules, are associated with PMF.
