The Influence of Depression, Anxiety and Somatization on the Clinical Symptoms and Treatment Response in Patients with Symptoms of Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia.
10.3346/jkms.2014.29.8.1145
- Author:
Yong June YANG
1
;
Jun Sung KOH
;
Hyo Jung KO
;
Kang Joon CHO
;
Joon Chul KIM
;
Soo Jung LEE
;
Chi Un PAE
Author Information
1. Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Korea. pae@catholic.ac.kr
- Publication Type:Original Article ; Observational Study ; Research Support, Non-U.S. Gov't
- Keywords:
Lower Urinary Tract Symptoms;
Benign Prostatic Hyperplasia;
Depression;
Anxiety;
Somatization;
Response
- MeSH:
Anxiety/epidemiology/*psychology;
Causality;
Comorbidity;
Depression/epidemiology/*psychology;
Humans;
Lower Urinary Tract Symptoms/epidemiology/prevention & control/*psychology;
Male;
Middle Aged;
Outcome Assessment (Health Care)/methods;
Prostatic Hyperplasia/epidemiology/*psychology/*therapy;
Psychometrics/methods;
Republic of Korea/epidemiology;
Risk Factors;
Severity of Illness Index;
Somatoform Disorders/epidemiology/*psychology;
Treatment Outcome
- From:Journal of Korean Medical Science
2014;29(8):1145-1151
- CountryRepublic of Korea
- Language:English
-
Abstract:
This is the first study to investigate the influence of depression, anxiety and somatization on the treatment response for lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH). The LUTS/BPH patients were evaluated with the Korean versions of the International Prostate Symptom Score (IPSS), the Patient Health Questionnaire-9 (PHQ-9), the 7-item Generalized Anxiety Disorder Scale (GAD-7) and the PHQ-15. The primary endpoint was a responder rate defined by the total score of IPSS (< or = 7) at the end of treatment. The LUTS/BPH severity was significantly higher in patients with depression (whole symptoms P = 0.024; storage sub-symptom P = 0.021) or somatization (P = 0.024) than in those without, while the quality of life (QOL) was significantly higher in patients with anxiety (P = 0.038) than in those without. Anxious patients showed significantly higher proportion of non-response (odds ratio [OR], 3.294, P = 0.022) than those without, while somatic patients had a trend toward having more non-responders (OR, 2.552, P = 0.067). Our exploratory results suggest that depression, anxiety and somatization may have some influences on the clinical manifestation of LUTS/BPH. Further, anxious patients had a lower response to treatment in patients with LUTS/BPH. Despite of limitations, the present study demonstrates that clinicians may need careful evaluation of psychiatric symptoms for proper management of patients with LUTS/BPH.
