Usefulness of Serum Leucine-Rich Alpha-2 Glycoprotein as a Disease Activity Biomarker in Patients with Rheumatoid Arthritis.
10.3346/jkms.2014.29.9.1199
- Author:
You Jung HA
1
;
Eun Jin KANG
;
Sang Won LEE
;
Soo Kon LEE
;
Yong Beom PARK
;
Jung Soo SONG
;
Sang Tae CHOI
Author Information
1. Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
- Publication Type:Original Article
- Keywords:
Leucine-Rich Alpha-2-Glycoprotein;
Arthritis, Rheumatoid;
Disease Activity;
Tumor Necrosis Factor-alpha
- MeSH:
Adult;
Aged;
Area Under Curve;
Arthritis, Rheumatoid/blood/*diagnosis;
Biological Markers/blood;
Blood Sedimentation;
C-Reactive Protein/analysis;
Enzyme-Linked Immunosorbent Assay;
Female;
Glycoproteins/*blood;
Humans;
Male;
Middle Aged;
ROC Curve;
*Severity of Illness Index;
Tumor Necrosis Factor-alpha/blood
- From:Journal of Korean Medical Science
2014;29(9):1199-1204
- CountryRepublic of Korea
- Language:English
-
Abstract:
Our study aimed to investigate whether serum leucine-rich alpha-2-glycoprotein (LRG) levels are elevated in patients with rheumatoid arthritis (RA). In addition, we assessed their correlation with disease activity parameters and pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-alpha). Our study included 69 patients with RA and 48 age- and sex-matched healthy controls. Serum concentrations of TNF-alpha and LRG were determined by enzyme-linked immunosorbent assay. Serum LRG concentrations were significantly elevated in patients with RA compared with those in healthy controls (30.8+/-14.4 vs. 22.2+/-6.1 ng/mL; P<0.001). In patients with RA, serum LRG levels were found to be correlated with disease activity score 28 (DAS28), erythrocyte sedimentation rate, and C-reactive protein levels (gamma=0.671; gamma=0.612; and gamma=0.601, P<0.001, respectively), but not with serum TNF-alpha levels. Serum LRG levels in patients with an active disease status (DAS28> or =2.6) were significantly higher than those in remission (DAS28<2.6) (36.45+/-14.36 vs. 24.63+/-8.81 ng/mL; P<0.001). Our findings suggest that serum LRG could contribute to the inflammatory process independent of TNF-alpha and it may be a novel biomarker for assessing inflammatory activity in patients with RA.
