The Feasibility of Short Term Prophylactic Antibiotics in Gastric Cancer Surgery.
10.5230/jgc.2010.10.4.206
- Author:
Jun Suh LEE
1
;
Han Hong LEE
;
Kyo Young SONG
;
Cho Hyun PARK
;
Hae Myung JEON
Author Information
1. Division of Gastrointestinal Surgery, Department of Surgery, The Catholic University of Korea, School of Medicine, Seoul, Korea. hmjeon@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Stomach neoplasm;
Antibiotic prophylaxis;
Anti-bacterial agents
- MeSH:
Anti-Bacterial Agents;
Antibiotic Prophylaxis;
Cefoxitin;
Centers for Disease Control and Prevention (U.S.);
Colon;
Comorbidity;
Fever;
Humans;
Incidence;
Prospective Studies;
Stomach Neoplasms
- From:Journal of Gastric Cancer
2010;10(4):206-211
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Most surgeons administer prophylactic antibiotics for 3 to 5 days postoperatively. However, the Center for Disease Control (CDC) guideline recommends antibiotic therapy for 24 hours or less in clean/uncontaminated surgery. Thus, we prospectively studied the use of short term prophylactic antibiotic therapy after gastric cancer surgery. MATERIALS AND METHODS: A total of 103 patients who underwent gastric cancer surgery between October 2007 and June 2008 were prospectively enrolled in a short term prophylactic antibiotics program. One gram of cefoxitin was administered 30 minutes before the incision, and one additional gram was administered intraoperatively for cases with an operation time over 3 hours. Postoperatively, one gram was administered 3 times, every 8 hours. Patients were checked routinely for fever. All cases received open surgery, and the surgical wounds were dressed and checked for Surgical Site Infection (SSI) daily. RESULTS: Of the 103 patients, 15 were dropped based on exclusion criteria (severe organ dysfunction, combined resection of the colon, etc). The remaining 88 patients were included in the short-term program of prophylactic antibiotic use. Of these patients, SSIs were detected in 8 (9.1%) and fever after 2 postoperative days was detected in 11 (12.5%). The incidence of SSIs increased with patient age, and postoperative fever correlated with operation time. CONCLUSIONS: Short term prophylactic antibiotic usage is feasible in patients who undergo gastric cancer surgery, and where there are no grave comorbidities or combined resection.
