Correlation between the Serum Luteinizing Hormone to Folliclestimulating Hormone Ratio and the Anti-Mullerian Hormone Levels in Normo-ovulatory Women.
10.3346/jkms.2015.30.3.296
- Author:
Jong Eun LEE
1
;
Sang Ho YOON
;
Hye Ok KIM
;
Eung Gi MIN
Author Information
1. Department of Obstetrics and Gynecology, Dongguk University Ilsan Hospital, Goyang, Korea. yoonprou@dumc.or.kr
- Publication Type:Original Article
- Keywords:
Anti-Mullerian Hormone;
LH/FSH Ratio;
Regular Menstruation;
Ovarian Reserve
- MeSH:
Adult;
Aging/blood;
Anti-Mullerian Hormone/*blood;
Female;
Follicle Stimulating Hormone/*blood;
Humans;
Luteinizing Hormone/*blood;
Menstruation/blood/physiology;
Middle Aged;
Ovarian Reserve/*physiology;
Ovulation/*blood/physiology;
Retrospective Studies;
Young Adult
- From:Journal of Korean Medical Science
2015;30(3):296-300
- CountryRepublic of Korea
- Language:English
-
Abstract:
Serum anti-Mullerian hormone (AMH) levels are regarded as an age-specific marker for predicting the ovarian reserve in women of reproductive age. Some studies have shown that the luteinizing hormone (LH)/follicle stimulating hormone (FSH) ratio can be used as a predictor of ovarian reserve. The purpose of this study was to assess the variation of LH/FSH ratio with aging and to evaluate the correlation between serum LH/FSH ratio and AMH levels as a predictor of the ovarian reserve in normo-ovulatory women. We retrospectively analyzed the day 3 serum hormone levels in 1,251 patients (age range: 20-50 yr) between January 2010 and January 2011. We divided the patients into 6 groups according to their age. Relation between serum AMH level and LH/FSH ratio was analyzed statistically. The serum AMH level was inversely correlated with age (r = -0.400, P < 0.001). A significant negative correlation was found between serum LH/FSH ratio and age (r = -0.213, P < 0.001). There was a significant partial correlation between serum LH/FSH ratio and AMH level when adjusted by age (r = 0.348, P < 0.001). The LH/FSH ratio could be considered as a useful marker for the ovarian reserve and could be applied to the clinical evaluation with AMH.
