Treatment Outcome and Mortality among Patients with Multidrug-resistant Tuberculosis in Tuberculosis Hospitals of the Public Sector.
10.3346/jkms.2011.26.1.33
- Author:
Doo Soo JEON
1
;
Dong Ok SHIN
;
Seung Kyu PARK
;
Jeong Eun SEO
;
Hae Sook SEO
;
Young Soo CHO
;
Joon Young LEE
;
Dae Yun KIM
;
Suck Jun KONG
;
Yun Seong KIM
;
Tae Sun SHIM
Author Information
1. Clinical Research Center, National Masan Tuberculosis Hospital, Masan, Korea. sooli10@hanmail.net
- Publication Type:Original Article
- Keywords:
Tuberculosis, Multidrug-Resistant;
Extensively Drug-Resistant Tuberculosis;
Treatment Outcome;
Mortality
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Antitubercular Agents/*therapeutic use;
Demography;
Drug Resistance, Multiple, Bacterial;
Drug Therapy, Combination;
Female;
Hospitals, Chronic Disease;
Humans;
Male;
Middle Aged;
Odds Ratio;
Predictive Value of Tests;
Retrospective Studies;
Sex Factors;
Treatment Outcome;
Tuberculosis, Multidrug-Resistant/drug therapy/*mortality
- From:Journal of Korean Medical Science
2011;26(1):33-41
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study was conducted to evaluate treatment outcome, mortality, and predictors of both in patients with multidrug-resistant tuberculosis (MDR-TB) at 3 TB referral hospitals in the public sector of Korea. We included MDR-TB patients treated at 3 TB referral hospitals in 2004 and reviewed retrospectively their medical records and mortality data. Of 202 MDR-TB patients, 75 (37.1%) had treatment success and 127 (62.9%) poor outcomes. Default rate was high (37.1%, 75/202), comprising 59.1% of poor outcomes. Male sex (adjusted odds ratio [aOR], 2.91; 95% confidence interval [CI], 1.13-7.49), positive smear at treatment initiation (aOR, 5.50; 95% CI, 1.22-24.90), and extensively drug-resistant TB (aOR, 10.72; 95% CI, 1.23-93.64) were independent predictors of poor outcome. The all-cause mortality rate was 31.2% (63/202) during the 3-4 yr after treatment initiation. In conclusion, the treatment outcomes of patients with MDR-TB at the 3 TB hospitals are poor, which may reflect the current status of MDR-TB in the public sector of Korea. A more comprehensive program against MDR-TB needs to be integrated into the National Tuberculosis Program of Korea.
