Changing Patterns of Serum and Bile Antibodies in Re-infected Rats with Clonorchis sinensis.
- Author:
Hongman ZHANG
1
;
Byung Suk CHUNG
;
Shunyu LI
;
Min Ho CHOI
;
Sung Tae HONG
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: Clonorchis sinensis; Serum; Bile juice; IgA; IgE; Rat; Re-infection
- MeSH: Animals; Antibodies, Helminth/analysis/*blood/*immunology/metabolism; Bile/*immunology; Clonorchiasis/blood/*immunology; Clonorchis sinensis/*immunology/*physiology; Immunoglobulin A/analysis/blood; Male; Rats; Rats, Sprague-Dawley; Time Factors
- From:The Korean Journal of Parasitology 2008;46(1):17-22
- CountryRepublic of Korea
- Language:English
- Abstract: Rats develop strong resistance to re-infection and super-infection by Clonorchis sinensis. The present study investigated the antibodies present in the sera and bile juice of rats that were primary infected and re-infected with C. sinensis. The serum level of specific IgG antibodies, which were elevated 2 wk of the primary infection, peaked at 4 wk and subsequently remained unchanged even during re-infection. The total IgE level in serum increased slowly from 388 ng / ml to 3,426 ng / ml beginning 2 wk after the primary infection, and remained high up to 8 wk but dropped to a normal level (259 ng / ml) after treatment. In resistant re-infected rats, the serum IgE level increased rapidly and peaked within 1 wk, whereas no increase was observed in immunosuppressed rats. The serum level of specific IgA antibodies was elevated beginning 1 wk after infection, and decreased 4 wk after treatment. The total bile IgA level unchanged during the primary infection but increased in treated and re-infected rats. The elevated levels of serum IgE and bile IgA indicate that these immunoglobulins may be correlated with the development of resistance to re-infection by C. sinensis in rats.
