Helicobacter pylori Infection with Atrophic Gastritis Is an Independent Risk Factor for Advanced Colonic Neoplasm.
- Author:
Ji Young LEE
1
;
Hye Won PARK
;
Ji Young CHOI
;
Jong Soo LEE
;
Ja Eun KOO
;
Eun Ju CHUNG
;
Hye Sook CHANG
;
Jaewon CHOE
;
Dong Hoon YANG
;
Seung Jae MYUNG
;
Hwoon Yong JUNG
;
Suk Kyun YANG
;
Jeong Sik BYEON
Author Information
- Publication Type:Original Article
- Keywords: Helicobacter pylori; Gastritis; Atrophy; Neoplasms
- MeSH: Antibodies; Atrophy; Colon*; Colonic Neoplasms*; Colonoscopy; Colorectal Neoplasms; Cross-Sectional Studies; Gastritis; Gastritis, Atrophic*; Helicobacter pylori*; Helicobacter*; Immunoglobulin G; Mass Screening; Risk Factors*; Stomach Neoplasms
- From:Gut and Liver 2016;10(6):902-909
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Helicobacter pylori is a major risk factor for atrophic gastritis (AG) and gastric cancer. The correlation between H. pylori, AG and colorectal neoplasm (CRN) has only been examined in a limited number of studies, and findings have been inconclusive. We aimed to investigate the association between H. pylori infection status, AG and advanced CRN. METHODS: This cross-sectional study investigated the relationship between the presence of serum anti-H. pylori IgG antibodies, AG, and advanced CRN in 6,351 consecutive asymptomatic subjects who underwent a screening colonoscopy. RESULTS: A total of 316 participants (5.0%) had advanced CRN. H. pylori seropositivity was 61.3%. In a univariate analysis, the presence of H. pylori infection was associated with advanced CRN (odds ratio [OR], 1.49; 95% confidence interval [CI], 1.17 to 1.91; p=0.001). H. pylori infection was associated with an increased risk of advanced CRN after adjusting for clinically relevant confounders (OR, 1.34; 95% CI, 1.04 to 1.72; p=0.023). H. pylori-related AG was significantly associated with the risk of advanced CRN (OR, 1.40; 95% CI, 1.03 to 1.91; p=0.030), whereas H. pylori infection without AG was not. CONCLUSIONS: H. pylori infection increased the risk of advanced CRN, especially when it was combined with AG. Strict colonoscopy screening and surveillance may be warranted in those with H. pylori-positive AG.
