A Case of Birt-Hogg-Dube Syndrome Diagnosed by a Folliculin Gene Mutation.
- Author:
Seung Bae YOON
1
;
Chan Kwon PARK
;
Min Kyu KANG
;
Seok Jong LEE
;
Dae Hee HAN
;
Chang Seok KI
;
Young Kyoon KIM
Author Information
1. Department of Internal Medicine, The Catholic University of Korea School of Medicine, Seoul, Korea. ckpaul@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Lung disease;
Gene deletion;
Pneumothorax
- MeSH:
Aged;
Birt-Hogg-Dube Syndrome;
Estrone;
Exons;
Female;
Gene Deletion;
Germ-Line Mutation;
Humans;
Kidney Neoplasms;
Lung;
Lung Diseases;
Pneumonia;
Pneumothorax;
Smoke;
Smoking
- From:Korean Journal of Medicine
2011;81(1):102-106
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Birt-Hogg-Dube (BHD) syndrome is a rare, autosomal-dominant disorder that is caused by germ-line mutations in the folliculin gene. Clinically, BHD syndrome is characterized by cutaneous follicle tumors, pulmonary cysts, spontaneous pneumothorax, and an increased risk of renal cancer. A 65-year-old woman was admitted to Seoul St. Mary's Hospital to treat pneumonia, and we found that she had experienced recurrent spontaneous pneumothorax and had bilateral multiple pulmonary cysts with no history of smoking. Mutation analysis of the folliculin gene identified a novel mutation in exon 9 (c.997_998delTC; p.Ser333ArgfsX56). Except for the lung manifestation, no other features of BHD syndrome were detected in this case. Here, we report a case of BHD syndrome that manifested only as lung disease with a novel mutation.
