Human Brain Astrocytes Mediate TRAIL-mediated Apoptosis after Treatment with IFN-gamma.
10.3349/ymj.2006.47.3.354
- Author:
Jeonggi LEE
1
;
Jeon Soo SHIN
;
In Hong CHOI
Author Information
1. Department of Microbiology, Institute for Immunology and Immunological Diseases and Brain Korea 21 Project for Medical Science, Seoul, Korea. inhong@yumc.yonse.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
IFN-gamma;
astrocyte;
TRAIL;
apoptosis
- MeSH:
Tumor Necrosis Factor-alpha/genetics/*metabolism;
TNF-Related Apoptosis-Inducing Ligand;
Membrane Glycoproteins/genetics/*metabolism;
Interferon Type II/*pharmacology;
Humans;
Cells, Cultured;
Astrocytes/*cytology/drug effects/metabolism;
Apoptosis Regulatory Proteins/genetics/*metabolism;
Apoptosis/*drug effects/physiology;
Antineoplastic Agents/*pharmacology
- From:Yonsei Medical Journal
2006;47(3):354-358
- CountryRepublic of Korea
- Language:English
-
Abstract:
TNF-related apoptosis inducing ligand (TRAIL) expressions were studied in primary human brain astrocytes in response to pro-inflammatory cytokines. When astrocytes were treated with IL-1beta TNF-alphaor IFN-gamma TRAIL was induced in cultured fetal astrocytes. In particular, IFN-gammainduced the highest levels of TRAIL in cultured astrocytes. When astrocytes were pre-reated with IFN-gamma they induced apoptosis in TRAIL-sensitive Peer cells. Our results suggest that IFN-gamma modulates the expression of TRAIL in astrocytes, which may enhance cytotoxic sensitivity of infiltrating immune cells or brain cells other than astrocytes during inflammation of brain.
