Risk Factors for the Progression of Intima-Media Thickness of Carotid Arteries: A 2-Year Follow-Up Study in Patients with Newly Diagnosed Type 2 Diabetes.
10.4093/dmj.2013.37.5.365
- Author:
Sang Ouk CHIN
1
;
Jin Kyung HWANG
;
Sang Youl RHEE
;
Suk CHON
;
You Cheol HWANG
;
Seungjoon OH
;
Kyu Jeung AHN
;
Ho Yeon CHUNG
;
Jeong Taek WOO
;
Sung Woon KIM
;
Young Seol KIM
;
Ja Heon KANG
;
In Kyung JEONG
Author Information
1. Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea. jik1016@dreamwiz.com
- Publication Type:Original Article
- Keywords:
Atherosclerosis;
Carotid artery intima-media thickness;
Diabetes mellitus type 2;
Risk factors
- MeSH:
Atherosclerosis;
Blood Pressure;
Blood Glucose;
Body Mass Index;
Cardiovascular Diseases;
Carotid Arteries;
Carotid Artery, Common;
Cholesterol;
Cholesterol, HDL;
Cholesterol, LDL;
Coronary Disease;
Diabetes Mellitus, Type 2;
Fasting;
Female;
Follow-Up Studies*;
Hemoglobin A, Glycosylated;
Humans;
Lipoproteins;
Male;
Risk Factors*;
Smoking
- From:Diabetes & Metabolism Journal
2013;37(5):365-374
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Intima-media thickness (IMT) of the carotid arteries is known to have a positive correlation with the risk of cardiovascular disease. This study was designed to identify risk factors affecting the progression of carotid IMT in patients with type 2 diabetes mellitus (T2DM). METHODS: Patients with newly diagnosed T2DM with carotid IMT measurements were enrolled, and their clinical data and carotid IMT results at baseline and 2 years later were compared. RESULTS: Of the 171 patients, 67.2% of males and 50.8% of females had abnormal baseline IMT of the left common carotid artery. At baseline, systolic blood pressure, body mass index and smoking in male participants, and fasting plasma glucose and glycated hemoglobin levels in females were significantly higher in patients with abnormal IMT than in those with normal IMT. Low density lipoprotein cholesterol (LDL-C) levels in males and high density lipoprotein cholesterol (HDL-C) levels in females at the 2-year follow-up were significantly different between the nonprogression and the progression groups. Reduction of the United Kingdom Prospective Diabetes Study (UKPDS) 10-year coronary heart disease (CHD) risk score after 2 years was generally higher in the nonprogression group than the progression group. CONCLUSION: LDL-C levels in males and HDL-C levels in females at the 2-year follow-up were significantly different between participants with and without progression of carotid IMT. Furthermore, a reduction in the UKPDS 10-year CHD risk score appeared to delay the advancement of atherosclerosis. Therefore, the importance of establishing the therapeutic goal of lipid profiles should be emphasized to prevent the progression of carotid IMT in newly diagnosed T2DM patients.
