Expression of Cyclooxygenase-2 and Its Correlation with Clinicopathologic Factors of Ampulla of Vater Cancer.
10.3346/jkms.2003.18.2.218
- Author:
Hong Joo KIM
1
;
Tae Sung SOHN
;
Kyu Taek LEE
;
Jong Kyun LEE
;
Seung Woon PAIK
;
Jong Chul RHEE
Author Information
1. Division of Gastroenterology and Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. tssohn@smc.samsung.co.kr
- Publication Type:Original Article
- Keywords:
Vater's Ampulla;
Duodenal Neoplasms;
Prostaglandin-Endoperoxide Synthase;
Ki-67 antigen;
Apoptosis;
Antigen CD34
- MeSH:
Adult;
Aged;
Ampulla of Vater*/enzymology;
Ampulla of Vater*/pathology;
Common Bile Duct Neoplasms/enzymology*;
Common Bile Duct Neoplasms/pathology*;
Female;
Human;
Immunoenzyme Techniques;
Isoenzymes/metabolism*;
Male;
Middle Aged;
Prostaglandin-Endoperoxide Synthase/metabolism*;
Statistics;
Survival Rate
- From:Journal of Korean Medical Science
2003;18(2):218-224
- CountryRepublic of Korea
- Language:English
-
Abstract:
There has been no report for the expression of cyclooxygenase-2 (COX-2) and its clinicopathologic and biologic significance in ampulla of Vater cancer. This study was aimed for the clarification of COX-2 expression and its biologic roles in ampulla of Vater cancer. Fourty-six patients with ampulla of Vater cancer were enrolled and their COX-2 expression and clinicopathologic features were analyzed. The median age of patients was 60 yr and the mean duration of follow-up was 35 months (range: 14-82 months). Immunohistochemical stainings for COX-2, Ki-67, CD34 and TUNEL staining were performed. The immunoreactive COX-2 expression was present in 24 (52.2%) patients of ampulla of Vater cancer and mainly localized in cytosolic and perinuclear region. There was no significant difference in the length of survival between COX-2 postive and negative group (p=0.9420 by Log Rank test). Also, there were no significant differences of proliferation index (p=0.326), apoptotic index (p=0.764) and microvessel density (p=0.135) between COX-2 positive and negative group. Initial pTNM stage (p=0.0028 by Log Rank test) and blood transfusion over 4 pints during operation (p=0.0254 by Log Rank test) were independent prognostic factor in patients with ampulla of Vater cancer. It is suggested that immunoreactivity of COX-2 is not correlated with clinicopathologic and biologic features of ampulla of Vater cancer.
