The Prognostic Value of the Charlson's Comorbidity Index in Patients with Prolonged Acute Mechanical Ventilation: A Single Center Experience.
10.4046/trd.2016.79.4.289
- Author:
Seung Eon SONG
1
;
Sang Hee LEE
;
Eun Jung JO
;
Jung Seop EOM
;
Jeong Ha MOK
;
Mi Hyun KIM
;
Ki Uk KIM
;
Min Ki LEE
;
Kwangha LEE
Author Information
1. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea. jubilate@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
Intensive Care Units;
Comorbidity;
Respiration, Artificial;
Prognosis
- MeSH:
Comorbidity*;
Humans;
Intensive Care Units;
Length of Stay;
Male;
Mortality;
Prognosis;
Proportional Hazards Models;
Respiration, Artificial*;
Retrospective Studies;
Survivors;
Tertiary Healthcare;
Ventilators, Mechanical
- From:Tuberculosis and Respiratory Diseases
2016;79(4):289-294
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The aim of our study was to evaluate the prognostic value of Charlson's weighted index of comorbidities (WIC) in patients with prolonged acute mechanical ventilation (PAMV, ventilator care ≥96 hours). METHODS: We retrospectively enrolled 299 Korean PAMV patients who were admitted in a medical intensive care unit (ICU) of a university-affiliated tertiary care hospital between 2008 and 2013. Survivors were defined as patients who survived for 60 days after ICU admission. RESULTS: The patients' mean age was 65.1±14.1 years and 70.6% were male. The mean ICU and hospital length of stay was 21.9±19.7 and 39.4±39.1 days, respectively. In addition, the 60-day mortality rate after ICU admission was 35.5%. The mean WIC was 2.3±1.8, with significant differences between nonsurvivors and survivors (2.7±2.1 vs. 2.1±1.7, p<0.05). The area under the curve of receiver-operating-characteristics curve for WIC was 0.593 (95% confidence interval [CI], 0.523–0.661; p<0.05). Based on Kaplan-Meier curves of 60-day survival, WIC ≥5 had statistically lower survival than WIC <5 (log-rank test, p<0.05). In a multivariate Cox proportional hazard model, WIC ≥5 was associated with poor prognosis (hazard ratio, 1.901; 95% CI, 1.140–3.171; p<0.05). The mortality rate of patients with WIC ≥5 was 54.2%. CONCLUSION: Our study showed a WIC score ≥5 might be helpful in predicting 60-day mortality in PAMV patients.
