Prognosis in Late-Onset Febrile Seizure.
10.26815/jkcns.2017.25.4.215
- Author:
Jihye BAEK
1
;
Soon Young HWANG
;
Jung Hye BYEON
;
So He EUN
;
Baik Lin EUN
;
Gun Ha KIM
Author Information
1. Department of Pediatrics, Korea University Guro Medical Center, Seoul, Korea. gunhaaa@korea.ac.kr, merr2020@gmail.com
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Febrile seizure;
Seizure;
Epilepsy;
Child
- MeSH:
Child;
Emergency Service, Hospital;
Epilepsy;
Follow-Up Studies;
Humans;
Kaplan-Meier Estimate;
Parents;
Prognosis*;
Prospective Studies;
Recurrence;
Risk Factors;
Seizures;
Seizures, Febrile*
- From:
Journal of the Korean Child Neurology Society
2017;25(4):215-220
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: There is a paucity of evidence about prognosis after a first febrile seizure in older children. We investigated the prognosis and potential risk factors associated with subsequent unprovoked seizures in children who had experienced a first febrile seizure over 6 years of age, which we termed as late-onset febrile seizure. METHODS: We included all patients six years or older who presented to the emergency department with a febrile seizure between 2009 and 2015. Clinical data was collected by chart review and parents were contacted for information on seizure progress. We used the Cox proportional-hazards model and Kaplan-Meier analysis for evaluating the risk factors for subsequent unprovoked seizures. RESULTS: Of 247 patients, we excluded 168 children who had a history of epilepsy, unprovoked, or febrile seizure and who were followed-up for period less than six months. Overall, 79 patients were classified as having had a first late-onset febrile seizure. During follow-up of 34.9±25.7(mean±SD) months, unprovoked seizure recurred in 7 of 79 patients (9%). The cumulative probability of seizure recurrence was 4% at 6 months, 6% at 1 year and 9% at 2 years. Clinical variables predictive of subsequent unprovoked seizures were not proved. CONCLUSION: This is the first multicenter study focusing on prognosis after a late-onset febrile seizure in children six years or older. The percentage of subsequent unprovoked seizure in patients with late-onset febrile seizure was 9% at 2 years of follow-up. Prospective follow-up study with longer duration is warranted.
