Two Cases of Multidrug-Resistant Human Immunodeficiency Virus Infection Treated with Atazanavir and Lopinavir/Ritonavir Combination Therapy.
10.3346/jkms.2008.23.4.737
- Author:
Heekyoung CHOI
1
;
Su Jin JEONG
;
Han Sung LEE
;
Bum Sik CHIN
;
Suk Hoon CHOI
;
Sang Hoon HAN
;
Myung Soo KIM
;
Chang Oh KIM
;
Jun Yong CHOI
;
Young Goo SONG
;
June Myung KIM
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. seran@yuhs.ac
- Publication Type:Case Report
- Keywords:
Double-Boosted Protease Inhibitor Therapy;
Atazanavir;
Lopinavir;
Salvage Therapy;
HIV Infections
- MeSH:
Adult;
Drug Resistance, Multiple, Viral;
Drug Therapy, Combination;
HIV Infections/*drug therapy;
HIV Protease Inhibitors/*administration & dosage;
Humans;
Male;
Oligopeptides/*administration & dosage;
Pyridines/*administration & dosage;
Pyrimidinones/*administration & dosage;
Ritonavir/*administration & dosage
- From:Journal of Korean Medical Science
2008;23(4):737-739
- CountryRepublic of Korea
- Language:English
-
Abstract:
The combination of atazanavir (ATV) and lopinavir/ritonavir (LPV/RTV) with nucleoside reverse transcriptase inhibitors (NRTI) has been used as a salvage regimen for human immunodeficiency virus (HIV)-positive patients. In this paper, we discuss two cases of HIV-positive patients who had long histories of virological failure following a heavy treatment of antiretroviral drugs, but then achieved virological suppression with double-boosted protease inhibitor (PI) regimens. In patients with multiple genotypic resistance to PIs and NRTIs, virological suppression can be achieved with a combination of ATV plus LPV/RTV with an NRTI backbone. The two cases in this report suggest that a combination of ATV plus LPV/RTV could be a useful salvage regimen for the subset of HIV-positive patients with limited treatment options.
