Expression of Wnt 1 and beta-catenin in epithelial ovarian cancer.
- Author:
Kyoung Ran YIM
1
;
Chan LEE
;
Yong Min KIM
;
Kwang Il KIM
;
Seung Jo KIM
;
Youn Yeung HWANG
;
Seon Yeong LEE
;
Young Jeong NA
;
Sang Geun JEONG
;
Yoe Un OH
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Pochon CHA University, Seongnam, Korea. ew97flora@hanmail.net
- Publication Type:Original Article
- Keywords:
Epithelial ovarian carcinoma;
Wnt 1;
beta-catenin;
Immunohistochemical staining
- MeSH:
beta Catenin;
Carcinoma, Endometrioid;
Early Diagnosis;
Epithelium;
Neoplasms, Glandular and Epithelial;
Ovarian Neoplasms
- From:Korean Journal of Obstetrics and Gynecology
2008;51(9):974-981
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: We were trying to identify the expression of Wnt 1 and beta-catenin in normal ovarian epithelium and epithelial ovarian tumor. METHODS: We used archival formalin-fixed and paraffin-embedded tissues from Comprehensive Gynecologic Cancer Center and the Department of Pathology at Bundang CHA Hospital from 2000 to 2005. Immunohistochemical staining for Wnt 1 and beta-catenin was performed on the ovarian epithelial tissues. Statistical analyses were performed with SPSS 10.1 for Windows and significance was defined as P<0.05. RESULTS: Of 114 cases, the cases were composed of 54 carcinomas, 40 borderline tumors, 12 benign tumors and 8 normal control ovarian tissues. Abnormal nucleocytoplasmic expression of beta-catenin was found in 4 endometrioid carcinomas. The nuclear expression of beta-catenin was found especially in the components of the endometrioid carcinoma (28.6%, P<0.05). Wnt 1 was overexpressed in all 9 clear cell carcinomas, but not frequent in the other types of malignant tumors (P<0.05). We found a statistically significant correlation between beta-catenin nuclear localization and endometrioid carcinomas. And we found a significant correlation between Wnt 1 expression and clear cell carcinomas. CONCLUSION: It does not seem that Wnt 1 over expression directly provoke the nuclear localization of beta-catenin. But, deregulation of beta-catenin and Wnt 1 may play a role in the pathogenesis of ovarian epithelial carcinogenesis of endometriod carcinoma and clear cell carcinoma. Evaluating this avenue of regulation of beta-catenin and Wnt protein in ovarian epithelial carcinoma may provide a new direction for early diagnosis and treatment in ovarian epithelial carcinoma and provide opportunities for making a certain biomarkers.
