The Expression of Programmed Death-1 in Circulating CD4+ and CD8+ T Cells during Hepatitis B Virus Infection Progression and Its Correlation with Clinical Baseline Characteristics.
- Author:
Ping XU
1
;
Yong Jing CHEN
;
Hui CHEN
;
Xiao Yan ZHU
;
Hua Feng SONG
;
Li Juan CAO
;
Xue Feng WANG
Author Information
1. The Affiliated Infectious Hospital of Soochow University, Suzhou, China.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Programmed death-1;
Hepatitis B virus;
Hepatitis B, chronic;
Liver cirrhosis;
Carcinoma, hepatocellular
- MeSH:
Adult;
CD4-Positive T-Lymphocytes/*metabolism;
CD8-Positive T-Lymphocytes/*metabolism;
Carcinoma, Hepatocellular;
Disease Progression;
Female;
Hepatitis B, Chronic/*diagnosis/immunology;
Humans;
Liver Cirrhosis;
Liver Neoplasms;
Male;
Programmed Cell Death 1 Receptor/*metabolism;
Viral Load
- From:Gut and Liver
2014;8(2):186-195
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Programmed death-1 (PD-1) expression was investigated in CD4+ and CD8+ T cells from hepatitis B virus (HBV)-infected patients at the chronic hepatitis B (CHB) infection, liver cirrhosis (LC), and hepatocellular carcinoma (HCC) stages. METHODS: PD-1 expression in circulating CD4+ and CD8+ T cells was detected by flow cytometry. The correlations between PD-1 expression and HBV viral load, alanine aminotransaminase (ALT) levels and aspartate aminotransferase (AST) levels were analyzed using GraphPad Prism 5.0. RESULTS: PD-1 expression in CD4+ and CD8+ T cells was significantly increased in both the CHB group and advanced-stage group (LC plus HCC). In the CHB group, PD-1 expression in both CD4+ and CD8+ T cells was positively correlated with the HBV viral load, ALT, and AST levels. However, in the LC plus HCC group, significant correlations between PD-1 expression and the clinical parameters were nearly absent. CONCLUSIONS: PD-1 expression in peripheral CD4+ and CD8+ T cells is dynamic, changes with HBV infection progression, and is related to HBV viral load and liver function, especially in CHB. PD-1 expression could be utilized as a potential clinical indicator to determine the extent of virus replication and liver injury.
