Effect of Ultra-marathon (308 km) Race on Bone Metabolism and Cartilage Damage Biomarkers.
- Author:
Kyung A SHIN
1
;
Al Chan KIM
;
Young Joo KIM
;
Yoon Hee LEE
;
Young Oh SHIN
;
Sang Hoon KIM
;
Young Sik PARK
;
Hee Seung NAM
;
Taikon KIM
;
Hyoung Seop KIM
;
Yongbum PARK
Author Information
- Publication Type:Original Article
- Keywords: Ultra-marathon; Osteoprotegerin; COMP; Osteocalcin
- MeSH: Biomarkers; Bone Resorption; Calcium; Cartilage; Continental Population Groups; Extracellular Matrix Proteins; Glycoproteins; Humans; Male; Osteocalcin; Osteogenesis; Osteoprotegerin
- From:Annals of Rehabilitation Medicine 2012;36(1):80-87
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: To evaluate the potential effects of a 308-km ultra-marathon on bone and cartilage biomarkers. METHOD: Venous blood samples were collected at pre-race, 100 km, 200 km, and 308 km checkpoints. The following markers of cartilage damage and bone metabolism were studied: osteocalcin (OC), osteoprotegerin (OPG), and calcium, phosphorous, and cartilage oligomeric matrix protein (COMP). RESULTS: Blood samples were taken from 20 male runners at four different checkpoints. Serum COMP was increased by 194.1% (130.7% at 100 km and 160.4% at 200 km). Serum OPG was significantly increased by 158.57% at 100 km and 114.1% at 200 km compared to the pre-race measures. OC was transiently suppressed at 200 km. Serum calcium and phosphorous concentrations decreased compared to the pre-race measures. CONCLUSION: This study showed that the 308-km ultra-marathon induced several changes, including transient uncoupling of bone metabolism, increased bone resorption, suppressed bone formation, and bone turnover and had a major impact on cartilage structure.
