Distribution and accumulation of 177Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles in the tissues of ICR mice.
10.14405/kjvr.2015.55.1.57
- Author:
Jin Joo HUE
1
;
Hu Jang LEE
;
Sang Yoon NAM
;
Jong Soo KIM
;
Beom Jun LEE
;
Young Won YUN
Author Information
1. College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Korea. beomjun@cbu.ac.kr, ywyun@cbu.ac.kr
- Publication Type:Brief Communication
- Keywords:
accumulation;
biodistribution;
177Lu;
nanotoxicity;
TCL-SPION
- MeSH:
Animals;
Body Weight;
Brain;
Epididymis;
Iron*;
Kidney;
Kinetics;
Liver;
Lung;
Male;
Mice;
Mice, Inbred ICR*;
Nanoparticles*;
Radioactivity;
Spleen;
Suspensions;
Veins
- From:Korean Journal of Veterinary Research
2015;55(1):57-60
- CountryRepublic of Korea
- Language:English
-
Abstract:
To investigate kinetics of free 177Lu and 177Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION), suspensions were intravenously injected into the tail vein of mice at a dose of 5 microCi/mouse or 15 mg/kg body weight, respectively. Free 177Lu radioactivity levels were highest in kidney followed by liver and lung 1 day post-injection. 177Lu-labeled TCL-SPION radioactivity in liver and spleen was significantly higher compared to that of other organs throughout the experimental period (p < 0.05). Radioactivity in blood, brain, and epididymis rapidly declined until 28 days. Based on these results, TCL-SPION could be a safe carrier of therapeutics.
