The Changes of Matrix Metalloproteinase-9 Expression in the Gastric Antral Mucosa after Helicobacter pylori Eradication: Immunohistochemical Study.
- Author:
Heok Soo AHN
1
;
In Hee KIM
;
Seung Ok LEE
;
Myoung Jae KANG
;
Dae Ghon KIM
;
Soo Teik LEE
Author Information
1. Department of Internal Medicine, Chonbuk National University College of Medicine, Chonju, Korea. Soo@moak.chonbuk.ac.kr
- Publication Type:Original Article ; English Abstract
- Keywords:
Helicobacter pylori;
Matrix metalloproteinase-9;
Eradication
- MeSH:
Adult;
Aged;
English Abstract;
Female;
Gastric Mucosa/*enzymology;
Gastritis/drug therapy/enzymology/microbiology;
Gelatinase B/*metabolism;
Helicobacter Infections/drug therapy/*enzymology/microbiology;
*Helicobacter pylori;
Humans;
Immunohistochemistry;
Male;
Middle Aged;
Peptic Ulcer/drug therapy/enzymology/microbiology;
Pyloric Antrum
- From:The Korean Journal of Gastroenterology
2004;43(2):90-95
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: In this study, we analysed the changes of matrix metalloproteinase-9 (MMP-9) expression in the gastric antral epithelium in respect to H. pylori eradication. METHODS: Twenty patients with H. pylori-positive chronic gastritis or peptic ulcer were studied. The expression of MMP-9 in the gastric antral biopsy specimens were compared before and after H. pylori eradication using immunohistochemical study. The positive rates and intensity of MMP-9 staining were evaluated at surface mucous cells and pyloric gland cells. RESULTS: The positive rate of MMP-9 staining in antral mucosal epithelial cells of H. pylori chronic gastritis is 63.8%. The positive rates of MMP-9 staining in the surface mucous cells and pyloric gland cells were 75.5% and 52.0% before H. pylori eradication, respectively. On the contrary, the rates were 85.5% and 82.0% after eradication. The MMP-9 overexpression in the pyloric gland cells were noticeably increased after H. pylori eradication. Strong positive staining of MMP-9 was increased significantly after H. pylori eradication in the pyloric gland cells. CONCLUSIONS: These results suggest that MMP-9 over-expression is associated with H. pylori infection as a host inflammatory response. The increased expression after H. pylori eradication indicates that MMP-9 may have a important role in remodeling or early tissue repairing process of gastric mucosa.
