Changes in the seroprevalence of IgG anti-hepatitis A virus between 2001 and 2013: experience at a single center in Korea.
10.3350/cmh.2014.20.2.162
- Author:
Sung Jun CHUNG
1
;
Tae Yeob KIM
;
Sun Min KIM
;
Min ROH
;
Mi Yeon YU
;
Jung Hoon LEE
;
Changkyo OH
;
Eun Young LEE
;
Seung LEE
;
Yong Cheol JEON
;
Kyo Sang YOO
;
Joo Hyun SOHN
Author Information
1. Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea. ktydoc@hanmail.net
- Publication Type:Original Article
- Keywords:
Hepatitis A virus;
IgG Anti-HAV;
Seroprevalence
- MeSH:
Adolescent;
Adult;
Age Factors;
Child;
Child, Preschool;
Female;
Hepatitis A/diagnosis/*epidemiology;
Hepatitis A Antibodies/*analysis;
Hepatitis A virus/*immunology;
Humans;
Immunoglobulin G/*analysis;
Infant;
Infant, Newborn;
Male;
Middle Aged;
Republic of Korea;
Seroepidemiologic Studies;
Sex Factors;
Young Adult
- From:Clinical and Molecular Hepatology
2014;20(2):162-167
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: The incidence of symptomatic hepatitis A reportedly increased among 20- to 40-year-old Korean during the late 2000s. Vaccination against hepatitis A was commenced in the late 1990s and was extended to children aged <10 years. In the present study we analyzed the changes in the seroprevalence of IgG anti-hepatitis A virus (HAV) over the past 13 years. METHODS: Overall, 4903 subjects who visited our hospital between January 2001 and December 2013 were studied. The seroprevalence of IgG anti-HAV was analyzed according to age and sex. In addition, the seroprevalence of IgG anti-HAV was compared among 12 age groups and among the following time periods: early 2000s (2001-2003), mid-to-late 2000s (2006-2008), and early 2010s (2011-2013). The chi-square test for trend was used for statistical analysis. RESULTS: The seroprevalence of IgG anti-HAV did not differ significantly between the sexes. Furthermore, compared to the seroprevalence of IgG anti-HAV in the early 2000s and mid-to-late 2000s, that in the early 2010s was markedly increased among individuals aged 1-14 years and decreased among those aged 25-44 years (P<0.01). We also found that the seroprevalence of IgG anti-HAV in individuals aged 25-44 years in the early 2010s was lower than that in the early 2000s and mid-to-late 2000s. CONCLUSIONS: The number of symptomatic HAV infection cases in Korea is decreasing, but the seroprevalence of IgG anti-HAV is low in the active population.
