Two Cases of Mycoplasma pneumoniae Pneumonia with A2063G Mutation in the 23S rRNA Gene in Siblings.
- Author:
Joo Hee HONG
1
;
Jin Kyong CHUN
;
Young UH
;
Ki Jin OH
;
Juwon KIM
;
Kap Jun YOON
Author Information
- Publication Type:Case Reports ; Research Support, Non-U.S. Gov't
- Keywords: Pneumonia; Macrolide; Mycoplasma pneumoniae; 23S rRNA
- MeSH: Anti-Bacterial Agents/pharmacology; Child; Child, Preschool; Drug Resistance, Bacterial/drug effects; Humans; Macrolides/pharmacology; Male; Mutation; Mycoplasma pneumoniae/*genetics/isolation & purification; Pneumonia, Mycoplasma/*diagnosis/microbiology/radiography; RNA, Ribosomal, 23S/*analysis; Real-Time Polymerase Chain Reaction; Sequence Analysis, RNA; Siblings
- From:Annals of Laboratory Medicine 2013;33(1):65-68
- CountryRepublic of Korea
- Language:English
- Abstract: We describe 2 cases of pneumonia caused by the same macrolide-resistant Mycoplasma pneumoniae in siblings. M. pneumoniae was identified using real-time PCR. Direct sequence analysis of the 23S rRNA gene revealed a point mutation in V domain (A2063G) of the 23S rRNA gene.
