PKR as a Regulator of Inflammasome Activation.
10.4167/jbv.2013.43.2.145
- Author:
Zahid MANZOOR
1
;
Young Sang KOH
Author Information
1. Department of Microbiology and Immunology, Jeju National University School of Medicine, Jeju, Korea. yskoh7@jejunu.ac.kr
- Publication Type:Letter
- Keywords:
Double-stranded RNA-dependent protein kinase;
High-mobility group box 1;
Inflammasome;
Nod-like receptor family pyrin domain containing 3
- MeSH:
Cytokines;
eIF-2 Kinase;
Immune System;
Inflammasomes;
Interleukin-18;
Interleukins;
Receptors, Pattern Recognition
- From:Journal of Bacteriology and Virology
2013;43(2):145-147
- CountryRepublic of Korea
- Language:English
-
Abstract:
Detection of pathogen by pattern recognition receptors leads to activation of inflammasome which plays a crucial role in immune system. The inflammasome regulates the release of cytokines, such as interleukin (IL)-1beta, IL-18 and high-mobility group box 1 (HMGB1). Double-stranded RNA-dependent protein kinase (PKR) is a critical component of an inflammatory complex. Recently, the critical role of PKR was reported in regulation of multiple inflammasomes.
