Clinical and Colonoscopic Characteristics of Primary Signet Ring Cell Carcinoma in Colorectum.
- Author:
Sung Hee PYO
1
;
Jeong Sik BYEON
;
Seung Jae MYUNG
;
Suk Kyun YANG
;
Hyung Joon LEE
;
Seung Il PYO
;
Jin Ho KIM
;
Jin Cheon KIM
;
Se Jin JANG
Author Information
1. Departments of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. jsbyeon@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Signet ring cell carcinoma;
Colorectal adenocarcinoma;
Colonoscopy;
Biopsy
- MeSH:
Abdominal Pain;
Adenocarcinoma;
Biopsy;
Carcinoma, Signet Ring Cell*;
Colon;
Colonoscopy;
Gastrointestinal Hemorrhage;
Humans;
Medical Records
- From:Korean Journal of Gastrointestinal Endoscopy
2006;33(5):278-284
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: A primary signet ring cell carcinoma (SRCC) in the colorectum is unusual. This study evaluated the clinical and colonoscopic characteristics of primary colorectal SRCC. METHODS: Twenty-eight patients diagnosed with a primary colorectal SRCC and 100 patients diagnosed with a primary colorectal nonmucinous adenocarcinoma were enrolled in this study. The medical records and colonoscopic findings were reviewed. RESULTS: The mean age was younger in the SRCC patients than in the nonmucinous adenocarcinoma patients (47.3+/-15.5 years vs. 60.3+/-10.4 years, p<0.001). In SRCC, hematochezia was less frequent while abdominal pain was more common (p<0.001). Duke stages A or B was rare in SRCC (4/28, 14.3% vs. 58/100, 58.0%, p<0.001). The colonoscopic features of Borrmann type 4 was more common in SRCC (10/28, 35.7% vs. 3/100, 3.0%, p<0.001). The occurrence of a tumor in the right colon was more frequent in SRCC (17/28, 60.7% vs. 20/100, 20.0%, p<0.001). The diagnostic yield of the first colonoscopic biopsy was lower in the SRCC patients (85.7% vs. 98.0%, p=0.021). CONCLUSIONS: Primary colorectal SRCC appears to occur in younger patients compared with nonmucinous adenocarcinoma. A more advanced stage and an infiltrative lesion such as Borrmann type 4 appears to be common and the diagnostic yield of a colonoscopic biopsy tends to be low in primary colorectal SRCC.
