A Case of Acute Cholestatic Hepatitis Associated with Orlistat.
- Author:
Doh Hyun KIM
1
;
Eun Hee LEE
;
Jae Chul HWANG
;
Jai Hak JEUNG
;
Do Hyun KIM
;
Jae Youn CHEONG
;
Sung Won CHO
;
Young Bae KIM
Author Information
1. Department of Gastroenterology, Ajou University College of Medicine, Suwon, Korea. sung-woncho@hotmail.com
- Publication Type:Case Report ; English Abstract
- Keywords:
Orlistat;
Acute cholestatic hepatitis;
Side effect
- MeSH:
Acute Disease;
Adult;
Anti-Obesity Agents/*adverse effects;
Cholestasis/*chemically induced/diagnosis;
English Abstract;
Female;
Hepatitis, Toxic/*diagnosis/etiology;
Human;
Lactones/*adverse effects;
Lipase/antagonists & inhibitors
- From:The Korean Journal of Hepatology
2002;8(3):317-320
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Orlistat(Xenical(R), Roche) is considered a safe and effective drug to treat obesity by reduced absorption of 30% digested fat. To date, no serious adverse effects affecting the liver have been published except a case of subacute hepatic failure leading to liver transplantation in a young women with moderate obesity treated with orlistat. We report a case of acute cholestatic hepatitis in a young woman with moderate obesity treated with orlistat: a 33-year-old female admitted for the evaluation of jaundice. Abdominal ultrasonography, ERCP, routine chemistry, viral markers, and a fine needle biopsy of liver were performed. Microscopic findings of the liver biopsy specimen were compatible with acute cholestatic hepatitis. After steroid therapy, liver function was improved.
