Analysis of high-risk factors for the recurrence of macular edema secondary to retinal vein occlusion based on the pathological mechanism of Western medicine and the syndrome characteristics of traditional Chinese medicine
10.3980/j.issn.1672-5123.2025.12.12
- VernacularTitle:基于西医病理机制与中医证候特征分析视网膜静脉阻塞性黄斑水肿复发的高危因素
- Author:
Liqian DIAO
1
;
Meng GAO
1
;
Yan SUN
1
;
Qingmin JIANG
1
;
Fei XIA
1
Author Information
1. Department of Ophthalmology, Affiliated Hospital of Shandong Second Medical University, Weifang 261053, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
retinal vein occlusion;
macular edema;
anti-vascular endothelial growth factor therapy;
cytokines;
retinal vessels
- From:
International Eye Science
2025;25(12):1965-1968
- CountryChina
- Language:Chinese
-
Abstract:
Retinal vein occlusion(RVO)is often accompanied by macular edema(ME), which is the main cause of visual impairment in patients. From the perspective of traditional Chinese medicine theory, the key pathogenesis lies in Qi stagnation and blood stasis, as well as internal retention of water and dampness, which is closely related to the dysfunction of internal organs such as liver depression and qi stagnation, spleen failure to function properly, and kidney deficiency with water retention. Although anti-vascular endothelial growth factor(VEGF)therapy has become the first-line treatment option for RVO-ME, some patients show a low response or no response to this therapy, resulting in recurrent ME. According to traditional Chinese medicine, such difficult-to-treat cases are often caused by long-term illness entering the meridians and the interplay of phlegm and blood stasis, or by deficiency of the body's vital energy and the lingering of pathogenic factors. Intervention should be carried out through therapeutic methods such as promoting blood circulation and diuresis, resolving phlegm and unblocking meridians, and strengthening the body's vital energy and eliminating pathogenic factors. At present, the pathogenesis of RVO-ME is not yet fully understood. Modern medicine believes that it may involve multiple factors such as retinal microstructure damage, abnormal blood flow and systemic diseases throughout the body, while traditional Chinese medicine emphasizes the overall connection between local lesions and the imbalance of Qi, blood, Yin and Yang throughout the body. This article systematically reviews the existing research achievements of traditional Chinese and Western medicine on RVO-ME, analyzes its possible high-risk factors, and provides a theoretical basis for formulating individualized treatment plans integrating the advantages of traditional Chinese and Western medicine for such patients.
