Analysis of Dry Eye Animal Models Based on Clinical Disease and Syndrome Characteristics in Traditional Chinese and Western Medicine
10.13422/j.cnki.syfjx.20251315
- VernacularTitle:基于中西医临床病证特点的干眼症动物模型分析
- Author:
Guicheng LIU
1
;
Yao CHEN
1
;
Binan WANG
1
;
Pei LIU
1
;
Jun PENG
2
;
Sainan TIAN
1
;
Qinghua PENG
1
Author Information
1. Hunan University of Chinese Medicine，Changsha 401208，China
2. The First Affiliated Hospital， Hunan University of Chinese Medicine，Changsha 401007，China
- Publication Type:Journal Article
- Keywords:
dry eye;
animal models;
combination of disease and syndrome;
characteristics of disease and syndrome
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(24):200-208
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveAccording to the etiology， pathogenesis， and clinical characteristics of dry eye （DE）， this paper aims to analyze existing DE animal models to provide recommendations for building more clinically relevant DE models that integrate traditional Chinese and Western medicine. MethodsBy the retrieval and analysis of relevant literature on DE animal experiments， combined with expert consensus， an evaluation scale was created to assess relevance from the perspectives of pathogenesis， diagnostic criteria， and traditional Chinese medicine （TCM） differentiation. On the basis of data provided by the literature， the clinical relevance was evaluated for the animal models constructed in the literature. ResultsAmong the existing methods for establishing a DE animal model， benzalkonium chloride eye-drop induction showed the highest clinical relevance， demonstrating 98% alignment with Western medicine. However， current models generally showed higher relevance to Western medicine than to TCM， and there was a lack of models integrating disease with syndrome. ConclusionAs DE involves diverse causes and pathogenesis， single-factor models cannot fully simulate the complex pathology of DE. Future research should focus on building multi-mechanism DE models， exploring new etiological directions， standardizing model evaluation systems， and promoting integration of traditional Chinese and Western medicine. This will help precisely simulate the pathophysiological process of human DE and provide more valuable guidance for clinical diagnosis and treatment， ultimately enhancing patient outcomes and satisfaction.
