Advances in the mechanisms underlying the contributions of thymocyte selection-associated high mobility group box to pathogen infections: a review
10.16250/j.32.1915.2025011
- VernacularTitle:胸腺细胞选择相关高迁移率族蛋白在病原体 感染中的作用机制研究进展
- Author:
Yuanfeng WANG
1
;
Tingting YING
1
;
Junru WU
1
;
Yuna HONG
1
;
Haorui GUO
1
;
Mingyue WANG
1
;
Zhenke YANG
1
;
Shuai WANG
1
Author Information
1. Department of Pathogenic Biology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, China; Xinxiang Municipal Key Laboratory of Pathogenic Biology, Xinxiang, Henan 453003, China
- Publication Type:Journal Article
- Keywords:
Thymocyte selection-associated high mobility group box protein;
Transcription factor;
Pathogen infection;
Mechanism
- From:
Chinese Journal of Schistosomiasis Control
2025;37(5):561-568
- CountryChina
- Language:Chinese
-
Abstract:
Thymocyte selection-associated high mobility group box (TOX), a member of the high mobility group protein super-family, plays an important role in T cell development, functional maintenance, and exhaustion. It has been recently found that TOX exerts critical immunoregulatory functions during pathogen infections, and TOX expression is strongly associated with the intensity and tolerance of host immune responses. This review systematically summarizes the structural and functional features of TOX and focuses on its expression dynamics, mechanisms of action, and immunomodulatory effects during viral, bacterial, and parasitic infections, which provides a theoretical support to better understanding of the role of TOX in infectious diseases and provides new insights into development of potential immunotherapeutic strategies targeting TOX.
