Progress in preclinical studies of xenogeneic lung transplantation and single-center technical experience
- VernacularTitle:异种肺移植临床前研究进展及单中心技术经验
- Author:
Xiaoting TAO
1
;
Xinzhong NING
1
;
Yong LIU
2
;
Guimei ZHANG
2
;
He XIAO
2
;
Shiyu LIN
1
;
Zizi ZHOU
1
;
Taiyun WEI
2
;
Chunxiao HU
2
;
Hongjiang WEI
2
;
Kun QIAO
1
Author Information
- Publication Type:TransplantationForefront
- Keywords: Xenogeneic lung transplantation; Organ shortage; Genetically modified pig; Ex vivo lung perfusion; Immunosuppression; Pathogen; Porcine endogenous retrovirus; Graft survival
- From: Organ Transplantation 2025;16(6):874-880
- CountryChina
- Language:Chinese
- Abstract: Lung transplantation is the ultimate therapeutic option for end-stage pulmonary diseases such as interstitial pneumonia, chronic obstructive pulmonary disease and pneumoconiosis. Currently, the shortage of allogeneic lung donors significantly limits the opportunity for end-stage lung disease patients to receive lung transplantation. In recent years, with the rapid development of biomedical engineering technologies, especially the major breakthroughs in genetic modification and cloning, xenogeneic lung transplantation has shown important potential for clinical translation. Among them, genetically modified pigs have become the most promising xenogeneic lung source due to the close similarity of organ size and physiological characteristics to humans, and the ability to perform targeted gene knockouts (such as α-Gal antigen knockout) to reduce the occurrence of hyperacute rejection. This article focuses on the research progress of porcine xenogeneic lung transplantation, systematically reviews the latest achievements and challenges in animal experiments and human trials, and introduces the technical experience accumulated by Shenzhen Third People's Hospital in the porcine-to-monkey xenogeneic lung transplantation model, in the hope of providing practical references for future research in this field.
