Association of short-term exposure to polycyclic aromatic hydrocarbons in ambient fine particulate matter with resident mortality: a case-crossover study
10.3969/j.issn.1006-2483.2025.06.002
- VernacularTitle:大气细颗粒物中多环芳烃短期暴露与居民死亡关联的病例交叉研究
- Author:
Sirong WANG
1
;
Zhi LI
2
;
Yanmei CAI
2
;
Chunming HE
2
;
Huijing LI
2
;
Yi ZHENG
1
;
Lu LUO
1
;
Ruijun XU
1
;
Yuewei LIU
1
;
Huoqiang XIE
2
;
Qinqin JIANG
2
Author Information
1. Department of Epidemiology , School of Public Health , Sun Yat-sen University , Guangzhou , Guangdong 510080, China
2. The Center for Disease Control and Prevention in Conghua District , Guangzhou , Guangdong 510900 , China
- Publication Type:Journal Article
- Keywords:
Polycyclic aromatic hydrocarbons;
Mortality;
Case-crossover study
- From:
Journal of Public Health and Preventive Medicine
2025;36(6):6-11
- CountryChina
- Language:Chinese
-
Abstract:
Objective To quantitatively assess the association of short-term exposure to polycyclic aromatic hydrocarbons (PAHs) in ambient fine particulate matter (PM2.5) with residents mortality. Methods A time-stratified case-crossover study was conducted from 2020 to 2022 among 10606 non-accidental residents by using the Guangzhou Cause of Death Surveillance System in Conghua District, Guangzhou. Exposure levels of PAHs in PM2.5 and meteorological data during the study period were obtained from the Center for Disease Control and Prevention in Conghua District and the China Meteorological Administration Land Data Assimilation System (CLDAS-V2.0), respectively. Conditional Poisson regression model was used to estimate the exposure-response association between PAHs and the mortality risk. Results Fluoranthene, chrysene, benzo[k]fluoranthene, benzo[a]pyrene, and indeno[1,2,3-cd]pyrene were significantly associated with an increased risk of mortality. For every one interquartile range increase in exposure levels, the non-accidental mortality risks increased by 8.33% (95% CI: 1.80%, 15.27%), 4.67% (95% CI: 1.86%, 7.57%), 6.07% (95% CI: 2.08%, 10.21%), 4.62% (95% CI: 1.85%, 7.47%), and 4.70% (95% CI: 0.53%, 9.03%), respectively. The estimated non accidental deaths attributable to exposure to fluoranthene, chrysene, benzo[k]fluorine, benzo[a]pyrene and indine[1,2,3-cd]pyrene were 5.91%, 6.08%, 6.51%, 6.46%, and 4.21%, respectively. Conclusions Short-term exposure to PAHs in PM2.5, including fluoranthene, chrysene, benzo[k]fluoranthene, benzo[a]pyrene and indine[1,2,3-cd]pyrene, was significantly associated with an increased risk of mortality among residents.
