Immunoregulatory mechanisms，development and application of terpenoid compounds from the Isodon genus
- VernacularTitle:香茶菜属萜类化合物免疫调节作用机制及开发应用
- Author:
Haiyue YANG
1
;
Qin LIU
1
;
Shiqing PENG
1
;
Guicai LIANG
1
;
Dan HE
1
;
Tao LI
1
;
Hong YAO
1
Author Information
1. Cancer Biotherapy Center，the Third Affiliated Hospital of Kunming Medical University/Yunnan Cancer Hospital/Peking University Cancer Hospital Yunnan，Kunming 650118，China
- Publication Type:Journal Article
- Keywords:
Isodon genus;
terpenoids;
immunomodulation;
molecular mechanisms;
signaling pathways;
structural modification
- From:
China Pharmacy
2025;36(22):2868-2872
- CountryChina
- Language:Chinese
-
Abstract:
Plants of the Isodon genus are an important source of terpenoids， with their constituents exhibiting rich structural diversity and remarkable biological activities （such as anticancer， antimicrobial， and anti-inflammatory properties）， demonstrating significant potential in the field of immunomodulation. This review summarizes recent advances in the immunomodulatory mechanisms， development and application of terpenoid compounds from the Isodon genus. It has been found that these compounds can modulate key inflammatory signaling pathways， such as nuclear factor-kappa B （NF-κB） and mitogen-activated protein kinases （MAPKs）， thereby blocking the cascade amplification of inflammatory factors， alleviating chronic inflammatory responses， and correcting immune dysregulation. Additionally， they can influence the polarization direction of macrophages and dynamically regulate the balance among different functional subsets of T cells， restoring immune homeostasis. Their clinical translation faces multiple challenges， including poor druggability， a lack of systematic safety data， the absence of precise pharmacodynamic biomarkers， complexities in clinical trial design， and unclear industrialization pathways.
