Evaluation of the preventive and therapeutic effects and safety of repetitive transcranial magnetic stimulation at different frequencies on radiation-induced brain injury
10.13491/j.issn.1004-714X.2025.05.013
- VernacularTitle:不同频率重复经颅磁刺激对放射性脑损伤的防治作用及安全性评价
- Author:
Tongzhou QIN
1
;
Liyuan LIU
1
;
Ling GUO
1
;
Guiqiang ZHOU
1
;
Yan ZHOU
1
;
Xia MIAO
1
;
Guirong DING
1
Author Information
1. Department of Radiation Protection Medicine, School of Preventive Medicine, Fourth Military Medical University, Xi’an 710032, China;Ministry of Education Key Lab of Hazard Assessment and Control in Special Operation Environment, Xi’an 710032, China.
- Publication Type:OriginalArticles
- Keywords:
Radiation-induced brain injury;
Repetitive transcranial magnetic stimulation;
Parameter;
Safety
- From:
Chinese Journal of Radiological Health
2025;34(5):702-712
- CountryChina
- Language:Chinese
-
Abstract:
Objective Radiation-induced brain injury (RIBI) is a common complication of radiotherapy for the head and neck tumors, and the current treatment methods are limited. Repetitive transcranial magnetic stimulation (rTMS), as a non-invasive neural regulation technique, has shown great potential in neuroprotection. However, the parameter selection and biological safety of rTMS in the prevention and treatment of RIBI have not been reported. Methods Using a mouse model of RIBI, this study employed three rTMS frequencies (5, 10, and 25 Hz) for intervention. Biochemical and pathological assays were conducted to identify the optimal stimulation parameter. Subsequently, this parameter was used to evaluate the biological safety in normal mice. Results Under the conditions of this experiment, rTMS interventions with all three frequencies could reduce the levels of serum brain injury markers (NSE and S100B) and inflammatory factors in mice (P < 0.001), and alleviate the morphological and structural damage of hippocampal tissue. The 10 Hz rTMS could significantly promote hippocampal neurogenesis in RIBI mice (P < 0.05). Furthermore, 10 Hz rTMS showed no significant effects on the cognitive function and mood of normal mice. The intervention did not significantly change the morphology and structure of the main organs, blood biochemical indicators, and the level of hippocampal neurogenesis in mice. Conclusion The 10 Hz rTMS is optimal for the prevention and treatment of RIBI with high biological safety.
